Melatonin-Dependent Regulation of Th17

Glebezdina N.S., Kuklina E.M.

Federal State Budget Establishment of Science Institute of ecology and genetics of microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russian Federation

Abstract.
Melatonin is a hormone that is produced mainly by pineal gland and plays a key role in regulation of fundamental organism functions, including the control of immune reactions. Immunomodulating effects of melatonin are determined by the expression of hormonal receptors by immune cells. In this regard, the most evident target of melatonin action is a populaion of IL-17-producing cells, Th17, since the intracellular hormone receptor serves as a differentiation factor for the cells. In respect that Th17 plays important role in immune defence, the regulation of their activity seems to contribute to the processes.

Keywords:
differentiation, Т-lymphocytes, melatonin, Th17

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Authors
Glebezdina Natalya S., glebezdina_n@mail.ru
Federal State Budget Establishment of Science Institute of ecology and genetics of microorganisms, Ural Branch of the Russian Academy of Sciences
PhD, junior researcher
614081, Russian Federation, Perm, Golev st., 13

Kuklina Elena M., ibis_07@mail.ru
Dr.Sc. (Biology), Senior researcher, Leading researcher