MINERAL DENSITY AND PROCESSES OF BONE TISSUE REMODELING IN CHILD POPULATION LIVING IN IODINE-DEFICIENT BIOGEOCHEMICAL TERRITORY

DOI: 10.22138/2500-0918-2022-19-5-422-432

F.H. Kamilov¹, T.I. Ganeev¹, V.N. Kozlov², R.R. Junusov¹, I.A. Men’shikova¹, A.N. Krjachko²

¹Federal State-Funded Educational Institution of Higher Education “Bashkir State Medical University” of Ministry of Health of Russia, Ufa, Russian Federation;

²Federal State-Funded Educational Institution of Higher Education “K. G. Razumovsky Moscow State University of Technologies and Management (FCU)”, Moscow, Russian Federation

Abstract. The territory of the Republic of Bashkortostan belongs to the regions with natural iodine deficiency in soil and water. The population of the republic is at risk of developing iodine deficiency conditions. The aim of the study was to evaluate the frequency of a decrease in bone mineral density and the level of markers of osteoresorption and bone formation in young schoolchildren and adolescents living in a region with natural iodine deficiency. Materials and methods. The survey covered 288 students of general education schools aged 11–12 and 309 students aged 14–15. Theauthors studiedconcentration of iodine in urine, plasma levels of thyroid hormones (thyroid stimulating hormone, free thyroxine), levels of calcium, magnesium, phosphorus, C-terminal telopeptides of type I collagen, activity of the bone isoenzyme of alkaline phosphatase. The volume of the thyroid gland, the mineral density of the bone tissue of the middle diaphysis of the tibia, the lower third of the radius were determined by ultrasonometry. Results and discussion. It was found that children have a high prevalence of iodine deficiency from 44% to 57.6% and a decrease in the concentration of iodine in the urine, an increase in the content of thyrotropin, calcium and magnesium in the blood plasma. Insufficient iodine supply leads to a slowdown in the intensity and imbalance of remodeling with a decrease in bone formation processes.

Keywords: iodine deficiency in children, bone strength, bone remodeling markers, mineral metabolism

Received 09.07.2022

For citation:
Kamilov F.H., Ganeev T.I., Kozlov V.N., Junusov R.R., Men’shikova I.A., Krjachko A.N. Mineral density and processes of bone tissue remodeling in child population living in iodine-deficient biogeochemical territory. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2022, Vol. 19, no. 5, pp. 422–432. DOI: 10.22138/2500-0918-2022-19-5-422-432 (In Russ)

REFERENCES
1. Abdulhabirova F.M., Bezlepkina O.B., Brovin D.N. and others. Clinical guidelines «Diseases and conditions associated with iodine deficiency». Problems of endocrinology. 2021, Vol. 67 (3), pp. 10-25, (In Russ.).
2. Ganeev T.I., Junusov R.R., Kamilov F.H. The state of phosphorus-calcium metabolism and bone tissue in experimental hypothyroidism. «The Science of the Young. (ERUDITIO JUVENIUM)» = Nauka molodyh. 2017, no. 2, pp. 158-164, (In Russ.).
3. Cardoso L.F., Maciel L.M., Paula F.J. The multiple effects of thyroid disorders on bone and mineral metabolism. Arq. Bras. Endocrinol. Metabol. 2014, Vol. 58 (5), pp. 452-63. DOI: 10.1590/0004-2730000003311.
4. Shuo Y.Y., Wang L., Baliock R.T. Thyroid hormone and the growth plate. Reviewe Endocrine Metabol. Disordes. 2006, no. 7, pp. 265-271.
5. Zimmermann M.B., Hess S.Y., Molinari L. et al. New reference values for thyroid volume by ultrasound in iodine- sufficient schoolchildren: a World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report. Am. J.Clin. Nutr. 2004, Vol. 79 (2), pp. 231-237. DOI: https://doi.org/10.1093/ajcn/79.2271.
6. WHO, UNISEF, ICCIDD. Assesment of deficiency disorders and monitoring their elimination: a guide for programme managers. — 3rd ed. Geneva. World Health Organization, 2007.
7. United Nations Children’s Fund (UNICEF), Global Iodine Network (GIN). Recommendations for monitoring salt iodization programs and assessing the status of iodine sufficiency of the population (Russian version). Clinical and experimental thyroidology = Klinicheskajaij eksperimental’naja tireoidologija. 2018, Vol. 54 (2), pp. 100-112. (In Russ.) DOI: 10.14341/ket 9734.
8. Galickaja V.V. Subclinical hyperthyroidism: diagnostic criteria and principles of treatment. European Thyroid Association Guideline Review 2015 «Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism». Clinical thyroidology.-Subklinicheskij gipertireoz: diagnosticheskie kriteri i iprincipy lechenija. Obzor rukovodstva Evropejskoj tireoidnoj associacii 2015 goda «Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism» Klinicheskaja tireoidologija, 2016, Vol. 6 (78), pp. 61-66.
9. Shhepljagina L.A., Rimarchuk G.V., Samohina E.O. and others. Bone strength in children: known and unknown facts. – Kostnaja prochnost’ u detej: izvestnye i neizvestnye fakty. M., 2011, 16 p.
10. Bassett J.H., van der Spek A., Logan J.G., Gogakos A., Bagchi-Chakraborty J., Williams A.J., et al. Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development. Endocrinology. 2015, Vol. 156(9), pp. 3098-3113. DOI: 10.1210/en.2014-1943.
11. Karakaş N.M., TulgarKınık S., Özdemir B., MuratoğluŞahin N., Tekindal M.A., Haberal A. Congenital Hypothyroidism and Bone Remodeling Cycle. J Clin Res Pediatr Endocrinol. 2017, Vol. 9 (2), pp. 106-110. DOI: 10.4274/jcrpe.3532.
12. Tsourdi E., Rijntjes E., Köhrle J., Hofbauer L.C., Rauner M. Hyperthyroidism and Hypothyroidism in Male Mice and Their Effects on Bone Mass, Bone Turnover, and the Wnt Inhibitors Sclerostin and Dickkopf-1. Endocrinology. 2015, Vol. 156 (10), pp. 3517-3527. DOI: 10.1210/en.2015-1073.
13. Lai Y., Wang H., Xia X., Wang Z., Fan C., Wang H., et al. Serum fibroblast growth factor 19 is decreased in patients with overt hypothyroidism and subclinical hypothyroidism. Medicine (Baltimore). 2016, Vol. 95 (39), e5001. DOI: 10.1097/MD.0000000000005001.
14. Gao C., Wang Y., Li T., Huang J., Tian L. Effect of subclinical hypothyroidism on the skeletal system and improvement with short-term thyroxine therapy. Oncotarget. 2017, Vol. 8 (52), pp. 90444-90451. DOI: 10.18632/oncotarget.19568.
15. Sato Y., Yoshihisa A., Kimishima Y., Kiro T. Subclinical Hypothyroidism is Associated with Adverse Prognosis in Heart Failure Patients. Can. J. Cardiol. 2018, Vol. 34 (1), pp.80-87.
16. Den’ga O.V., Kolesnik K.A. The role of thyroid hormones in the integral regulation of bone metabolism in normal and hypothyroid patients. Tauride Medical and Biological Bulletin. = Rol’ tireoidnyh gormonov v integral’noj reguljacii kostnogo metabolizma v norme i pri gipotireoze. Tavricheskij mediko-biologicheskij vestnik. 2014, Vol. 15(1), pp. 331-337.
17. Vella K.R., Hollenberg A.N. The actions of thyroid hormone signaling in the nucleus. Mol Cell Endocrinol. 2017, 458, pp.127-135. DOI: 10.1016/j.mce.2017.03.001.

Authors
Feliks H. Kamilov
Federal State-Funded Educational Institution of Higher Education “Bashkir State Medical University” of Ministry of Health of Russia
D.M.Sc., professor, Professor of the Department of Biological Chemistry
3 Lenin Street Ufa Bashkortostan Russian Federation 450000
kamilovfx@yandex.ru

Timur I. Ganeev
Federal State-Funded Educational Institution of Higher Education “Bashkir State Medical University” of Ministry of Health of Russia
Cand. med. Sciences, associate professor, Associate Professor of the Department of Orthopedic Dentistry with IDPO courses
3 Lenin Street Ufa Bashkortostan Russian Federation 450000
ganey87@gmail.com

Valery N. Кozlov
Bashkir Institute of Technologies and Management (branch) Federal State-Funded Educational Institution of Higher Education K. G. Razumovsky Moscow State University of Technologies and Management (FCU)
Dr. Biol. Sciences, Head of the Research Center “Food Technologies”
34 Smolenskaya Street Meleuz Bashkortostan Russian Federation 453850
bioritom@mail.ru

Renat R. Junusov
Federal State-Funded Educational Institution of Higher Education “Bashkir State Medical University” of Ministry of Health of Russia
Cand. med. Sciences,Associate Professor of the Department of Orthopedic Dentistry with IDPO courses
3 Lenin Street Ufa Bashkortostan Russian Federation 450000
zubnik88@mail.ru

Irina A. Men’shikova
Federal State-Funded Educational Institution of Higher Education “Bashkir State Medical University” of Ministry of Health of Russia
Cand. med. Sciences,Associate Professor of the Department of Biological Chemistry
3 Lenin Street Ufa Bashkortostan Russian Federation 450000
i-menshikova@bk.ru

Alexey N. Kryachko
Bashkir Institute of Technologies and Management (branch) Federal State-Funded Educational Institution of Higher Education “K. G. Razumovsky Moscow State University of Technologies and Management (FCU)”
Postgraduate student of the Department of Food Production Technology
34 Smolenskaya Street Meleuz Bashkortostan Russian Federation 453850
erakond@bk.ru