Morphological Feature of the Intestine in Gastroschisis

Bisaliev B.N., Tsap N.A., Krohina N.B., 
Chudakov V.B., Kobeleva Y.M.

Abstract.

Morphological studies intestine are carried out on histological preparations of autopsies of 19 children who died of gastroschisis over the period 2000-2010 g.g. (main group) and 10 children have died from extraintestinal pathologies, with normally formed bowel (control group). Aggressive effects of amniotic fluid in gastroschisis intestine can lead to immaturity of neurons, atrophy and hypoplasia of smooth muscle, submucosal edema at birth, which can cause intestinal gipomotors, wich characteristic of gastroschisis in the postoperative period. Thickening and sclerosis of submucosal due to multiple sclerosis and hyperplasia of lymphoid tissues may determine the functional deficit and a prerequisite for the development of malabsorption. Hypertrophy of the serous membrane and its transformation into a kind of fibrin coating reflects a defensive response to the pathological effects of amniotic fluid and has signs of productive inflammation. Morphometric study materials intestines of children who died of gastroschisis in the age aspect revealed that the maturity of the nerve ganglia increased in parallel there was a restoration of muscle and serous layers. Alterative, hypoplastic and inflammatory are positive changes occurring in the wall of the intestine in gastroschisis is a reversible phenomenon.

Keywords:

gastroschisis, intestine, morphological structure

Authors

Bisaliev Baurzhan N.
Ural State of Medical Academy, Department of the Pediatric Surgery
e-mail: bisaliew@yandex.ru

Tsap Natalya A. 
Ural State of Medical Academy, uperintendent of the Department of Pediatric Surgery
e-mail: tsapna-ekat@rambler.ru.

Krohina Nataly B. 
Institute of immunology and physiology of UrO of the Russian Academy of Sciences.
e-mail: krohina@e1.ru

Chudakov Vladislav B.
Regional Children Clinical Hospital №1, chief Department of the new born surgery
e-mail: chudakov@e1.ru

Kobeleva Yaroslava M.
Sverdlovsk Regional Section.

Russia, 620149, Ekaterinburg, street Serafimy Derjabinoj, 32, Regional Children Clinical Hospital №1, surgical unit №4