MORPHOMETRIC CHANGES OF THE MYOCARDIUM AND PANCREAS IN PARACETAMOL POISONING
DOI: 10.22138/2500-0918-2025-22-3-294-302
A.I. Zudova¹,², T.A. Timofeeva², K.B. Usarova², I.A. Gatina², E.V. Kazarina², M.V. Bragin², E.A. Petri², A.A. Kreis², E.A. Mukhlynina¹, L.V. Solomatina¹
¹Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation;
²Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Yekaterinburg, Russian Federation
Abstract. The steady increase in the incidence of heart and pancreatic diseases, as well as the lack of information on the effect of paracetamol on the structure of these organs, necessitate the study of morphometric changes in poisoning with this drug, especially in the context of oral use of this drug and the growing number of cases of paracetamol overdose. Paracetamol, often used as an analgesic and antipyretic, has a narrow therapeutic index, which makes its toxicity a particularly relevant topic for clinical and pathophysiological research. The purpose of the study. To analyze morphometric changes in the pancreas and myocardium of C57Bl/6 mice with acute paracetamol poisoning. Materials and methods. The experiment was conducted on male C57Bl/6 mice (n=21), divided into intact, control, and experimental groups. Paracetamol (600 mg/kg) was administered intraperitoneally to the experimental group, and saline solution was administered to the control group. After 6 hours, the pancreas and heart were removed for histological and morphometric studies. Conclusions. In acute paracetamol poisoning in C57Bl/6 mice in the early stages (after 6 hours) There are no morphometric and histological signs of dystrophic-necrotic changes in the heart or acute pancreatitis in the pancreas.
Keywords: morphometric changes, myocardium, pancreas, paracetamol poisoning
There is no conflict of interest
Contact information of the author responsible for correspondence:
Alevtina I. Zudova
tina.zudova@mail.ru
Recieved 24.04.2025
For citation: Zudova A.I., Timofeeva T.A., Usarova K.B., Gatina I.A., Kazarina E.V., Bragin M.V., Petri E.A., Kreis A.A., Mukhlynina E.A., Solomatina L.V. Morphometric changes of the myocardium and pancreas in paracetamol poisoning. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2025, Vol. 22, no. 3, pp. 294–302. DOI: 10.22138/2500-0918-2025-22-3-294-302 (In Russ)
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Authors
Alevtina I. Zudova
Federal State Budgetary Educational Institution of Higher Education «Ural State Medical University» of the Ministry of Health of the Russian Federation
Assistant of the Department of Normal Physiology of the Ural State Medical University, Junior Researcher Laboratory of Inflammation Immunology IIF UB RAS
tina.zudova@mail.ru
Yekaterinburg, Russian Federation
Tatyana A. Timofeeva
Ural State Medical University of the Russian Ministry of Health
Student of the Institute of Clinical Medicine
timofeevatania24@gmail.com
Yekaterinburg, Russian Federation
Kamila B. Usarova
Ural State Medical University of the Russian Ministry of Health
Student of the Institute of Clinical Medicine
kamilausarova47@gmail.com
Yekaterinburg, Russian Federation
Irina A. Gatina
Ural State Medical University of the Russian Ministry of Health
Student of the Institute of Clinical Medicine
ira.gatina.04@mail.ru
Yekaterinburg, Russian Federation
Elizaveta V. Kazarina
Ural State Medical University of the Russian Ministry of Health
Student of the Institute of Clinical Medicine
aazzaazz69.40@gmail.com
Yekaterinburg, Russian Federation
Maxim V. Bragin
Ural State Medical University of the Russian Ministry of Health
Student of the Institute of Clinical Medicine
Braginmaxim11@mail.ru
Yekaterinburg, Russian Federation
Ekaterina A. Petri
Ural State Medical University of the Russian Ministry of Health
Student of the Institute of Clinical Medicine
Petriekaterina01@gmail.com
Yekaterinburg, Russian Federation
Alina A. Kreys
Ural State Medical University of the Russian Ministry of Health
Student Institute of Clinical Medicine
kreal1702@yandex.ru
Yekaterinburg, Russian Federation, 620028
Elena A. Mukhlynina
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
PhD, Senior Researcher, Laboratory of Morphology and Biochemistry, IIPh UB RAS
elena.mukhlynina@yandex.ru
Yekaterinburg, Russian Federation
Liliya V. Solomatina
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
PhD, Senior Researcher, Laboratory of Inflammation Immunology, IIPh UB RAS
slv10@list.ru
Yekaterinburg, Russian Federation