Multipotent Mesenchymal Stromal Cells in Regeneration of Defects Burned Wounded Skin in Norm and under Hyperglycemia in Mice
Lykov A.P., Bondarenko N.A., Nikonorova Yu.V., Poveshchenko O.V., Miller T.V., Poveshchenko A.F.
FSBI «Scientific institution of clinical and experimental lymphology» SB RAMS, Novosibirsk, Russian Federation
Abstract. Study of efficiency of therapy of bone marrow multipotent mesenchymal stromal cells (BM-MMSC) burn wounds in norm and hyperglycemia-induced streptozotocin in mice. It is shown that the introduction BM-MMSC, conditioned media from BM-MMSC or fibroblasts promotes rapid epithelization of wound skin defect in normal and hyperglycemia.
Keywords: hyperglycemia, diabetes mellitus, diabetic food ulcer, multipotent mesenchymal stromal cells
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Authors
Lykov Alexander P., e-mail: aplykov2@mail.ru
FSBI «SI CEL» SB RAMS laboratory of cellular technologies
PhD, leading researcher
Russian Federation, 630117, Novosibirsk, Timakova st., building 2
Bondarenko Natalia A., e-mail: bond802888@yandex.ru
PhD, junior researcher
Nikonorova Yulija V.
junior researcher
Poveshchenko Olga V., e-mail: poveschenkoov@yandex.ru
PhD, head of the laboratory
Miller Tatjana V., e-mail: tmw87@mail.ru
postgraduate student laboratory of physiology protective system
Poveshchenko Alexander F., e-mail:poveshchenkoa200@mail.ru
MD, head of the laboratory