Oxidative Lesion Correction Efficiency with Benzimidazole Derivative Bemythyl in Cerebral Hypoxia

Chereshnev V.A., Gulyaeva I.L., Sergeeva S.A.

Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Yekaterinburg, Russian Federation; State educational institution of the higher vocational training «Perm state medical academy name ac. E.A. Wagner of the Ministry of health of the Russian Federation», Perm, Russian Federation; SUESC «All-Russian Scientific Center for Safety of Biologically Active Substances», Staraya Kupavna, Russian Federation

Abstract. The article presents the results of pharmacokinetic studies of benzimidazole derivative actoprotector bemythyl, its ability to accumulate in the brain tissue and other organs at various modes of administration. The experimental data obtained by studying the distribution bemythyl in organs and tissues of rats by a single and course ingestion of the drug evidence of the intensive transition bemythyl from the blood into the tissues and organs, including the brain. The ability of the drug to penetrate the blood-brain barrier and accumulate in the tissues of the brain in course administration allows to make a conclusion about the possibility of pharmacological correction of hypoxia and oxidative damage of the brain by actoprotector bemythyl.

Keywords: the brain, hypoxia, oxidative stress, bemythyl, the blood-brain barrier

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Authors
Chereshnev Valerij A.
Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences
doctor of medicine, Professor, academician of the Russian Academy of Sciences, academician of the Russian Academy of medical Sciences, Director
620049, st. Pervomaiskaya, 106, Yekaterinburg, Russian Federation

Gulyaeva Inna L., pimenova774@yandex.ru
State educational institution of the higher vocational training «Perm state medical academy name ac. E.A. Wagner of the Ministry of health of the Russian Federation»
doctor of medicine, associate Professor, head of Department
614000, st. Petropavlovskaya, 26, Perm, Russian Federation

Sergeeva Svetlana A., sa-sergeeva@inbox.ru
SUESC «All-Russian Scientific Center for Safety of Biologically Active Substances»
doctor of medicine, Professor
142450, Kirov street, 23, Moscow region, Staraya Kupavna, Russian Federation