Assessment of the Role of Some Candidate Genes in the Pathophysiology of Great Obstetrical Syndromes

УДК 618.3

DOI: 10.22138/2500-0918-2019-16-4-432-449

E.V. Kudryavtseva, V.V. Kovalev, I.V. Ugarov, V.V. Dudurich, I.D. Terebenina, I.Yu. Vaganova

Ural State Medical University, Yekaterinburg, Russian Federation

Abstract. Objective: to assess the effect of certain genetic polymorphisms and their combinations on the risk of pregnancy complications.Materials and research methods: The frequency of occurrence of genetic polymorphisms in genes of the hemostatic system, genes of the folate cycle, genes of the renin-angiotensin-aldosterone system, genes of cytokines, and genes of “endothelial dysfunction” in patients with a history of complicated and uncomplicated pregnancy was estimated. The study included 102 Caucasian women aged 21 to 45 years — 59 of them were the main group (women with a history of pregnancy complications) and 43 women who had no history of gestational complications, the control group.Results. There were no significant differences in the frequency of occurrence of polymorphic alleles and genotypes between the studied groups. However, in the presence of certain adverse combinations, carriage of polymorphic alleles may occur. The most unfavorable are the simultaneous carriage of homozygous «wild» genotypes of the F7 and F13 genes (F7 G10976A GG + F13 G103A GG), a combination of the polymorphic homozygous genotype of the MTRR gene and heterozygous carriage of the polymorphism in the MTHFR gene (MTRR A66G TT776 + AA + MTRR ), a combination of polymorphic hetero- or homozygous polymorphism in the ACE gene with hetero- or homozygous polymorphic genotypes in the AGT or ADD1 gene (ACE Alu I / D ID or DD + AGT A704G AG or GG, or ADD1 G1378T GT or TT).Conclusions. Polymorphisms of the studied genes are found equally often both in the main and in the control group. The negative effect of the “wild” and polymorphic alleles in the studied genes can occur with the combined carriage of unfavorable variants in different genes. Using analysis of these polymorphisms in routine clinical practice to assess the risk of pregnancy complications is not advisable.

Keywords: Folate cycle genes, thrombophilia, endothelial dysfunction, great obstetrical syndromes, genetic polymorphism

Received 08.10.2019

For citation: Kudryavtseva E.V., Kovalev V.V., Ugarov I.V., Dudurich V.V., Terebenina I.D., Vaganova I.Yu. Assessment of the Role of Some Candidate Genes in the Pathophysiology of Great Obstetrical Syndromes. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 4, pp. 432–449. DOI: 10.22138/2500-0918-2019-16-4-432-449 (In Russ)

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Authors
Elena V. Kudryavtseva
Ural State Medical University
PhD, associated professor, Department of Obstetrics and Gynecology, Faculty of Advanced Studies
Repina str. 3 Yekaterinburg 620109 Russian Federation
elenavladpopova@yandex.ru

Vladislav V. Kovalel
Ural State Medical University
Ph.D., doctor of medicine, professor, head of Department of Obstetrics and Gynecology, Faculty of Advanced Studies
Repina str. 3 Yekaterinburg 620109 Russian Federation
vvkovalev55@gmail.com

Igor V. Ugarov
ExDzhen Cybernetics LLC
PhD, Biophysicist, Director General
Verhoyanskaya str. 18/2-4 Moscow 129344 Russian Federation
iugarov@yandex.ru

Vasilisa V. Dudurich
Genetic Laboratory «Cerbalab»
Director of Development, Genetic consultant, biologist
Bolshoy Prospect VO d.90 building 2 lit. «3» St. Petersburg 119106 Russian Federation
vdudurich@cerbalab.ru.

Irina Yu. Vaganova
Ural State Medical University
Student of the faculty of pediatrics
Repina str. 3 Yekaterinburg 620109 Russian Federation
summer2403@mail.ru

Irina D. Terebenina
Ural State Medical University
Student of the faculty of pediatrics
Repina str. 3 Yekaterinburg 620109 Russian Federation
summer2403@mail.ru