ESTIMATION OF PLATELET PARAMETERS WITH AN AUTOMATED HEMATOLOGY ANALYZER IN PATIENTS WITH LIVER CIRRHOSIS
DOI: 10.22138/2500-0918-2019-16-3-351-356
A.Yu. Maksimova, N.V. Garenskih, E.N. Bessonova, V.V. Bazarniy
Ural State Medical University of the Ministry of Health of Russia, Ekaterinburg, Russian Federation;
Sverdlovsk Regional Clinical Hospital No.1, Ekaterinburg, Russian Federation
Abstract. The aim of this research is to assess the platelet parameters in patients with liver cirrhosis.Materials and methods. 208 patients with liver cirrhosis (LC) were examined and divided into subgroups depending on the severity of the disease according to the Child-Pugh classification (C-P). Platelet parameters such as platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) were determined using an automated hematology analyzer.Results. In cases of liver cirrhosis, the number of platelets and their mean volume tended to decrease as the disease was progressing. In patients with viral liver cirrhosis, more apparent thrombocytopenia was observed compared to cholestatic and alcoholic liver cirrhosis.Conclusion. Platelet parameter measurements with the use of an automated hematology analyzer allow evaluating the pathogenetic mechanisms of thrombocytopenia in LC. At an early stage of LC, platelet hyperdegradation play an important role in the development of thrombocytopenia related to splenomegaly, and as the severity of the disease increased, this pathology becomes hypoproductive.
Keywords: liver cirrhosis, thrombocytopenia, platelet parameters
Received 22.03.2019
For citation: Maksimova A.Yu., Garenskih N.V., Bessonova E.N., Bazarniy V.V. Estimation of Platelet Parameters with an Automated Hematology Analyzer in Patients with Liver Cirrhosis. Vestn. Ural. Med. Akad. Nauki.=Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 3, pp. 351-356. DOI: 10.22138/2500-0918-2019-16-3-351-356 (In Russ)
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Authors
Arina Yuryevna Maksimova
Ural State medical University of the Ministry of Health of Russia
Junior Researcher, of Central Research Laboratory, Department of General Pathology
3 Repin St., Ekaterinburg, 620028, Russian Federation
oreshek92@list.ru
NataliaVitalievna Garenskih
Sverdlovsk Regional Clinical Hospital #1
Candidate of Medical Science, Head of Blood Transfusion Station
185, Volgogradskaya St., Ekaterinburg, 620102, Russian Federation
Elena Nikolaevna Bessonova
Sverdlovsk Regional Clinical Hospital # 1
PhD, Head of Gastroenterology Department
185, Volgogradskaya St., Ekaterinburg, 620102, Russian Federation
ben@okb1.ru
Vladimir Viktorovich Bazarniy
Ural State Medical University of the Ministry of Health of Russia
PhD, Professor of the Department of Clinical Laboratory Diagnostics and Bacteriology
3 Repin St., Ekaterinburg, 620028, Russian Federation
vlad-bazarny@yandex.ru