STUDY OF HUMORAL IMMUNE PROTECTION FACTORS IN CHILDREN WITH CHRONIC ADENOIDITIS
DOI: 10.22138/2500-0918-2026-23-1-51-63
A.O. Izumov¹, T.I. Ryabichenko¹,², O.O. Obukhova², А.Е. Karavozova¹,
V.E. Menshchikova¹, T.V. Kartseva¹, V.G. Selyatitskaya²
¹Novosibirsk State Medical University, Novosibirsk, Russian Federation;
²Federal State Budgetary Scientific Institution «Federal Research Center for Fundamental
and Translational Medicine», Novosibirsk, Russian Federation
Abstract. Studying the state of the immune system may make it possible to develop pathogenetically sound measures for the prevention and treatment of chronic diseases of the upper respiratory tract. Goal. To study the serum levels of certain cytokines (IL-10, IFNy) and other indicators characterizing the immune response (IgA, VEGF) in children with chronic adenoiditis and to evaluate the effectiveness of inclusion in the rehabilitation program in the postoperative period of dietary supplements (B. longum MS-42). Materials and methods. At the first stage, 100 preschool children with a diagnosis of J35.9 were examined. The patients were divided into two groups depending on the severity of the disease and the phase of the course. All patients underwent blood sampling to determine serum levels of IL-10, IFNy, IgA, and VEGF. The second stage involved 100 children of the same age. All children underwent surgical treatment in the amount of adenoidectomy; in group 2, along with the surgical treatment, the children received nasopharyngeal irrigation with a probiotic solution for 30 days. The levels of IL-10, IFNy, IgA, and VEGF were determined in all patients before and 30 days after the start of therapy. Results and conclusion. Preschool children with chronic nasopharyngeal inflammation experience intense immune system activity due to high production of IgA and IFN-γ and higher concentrations of IL-10 and VEGF in patients with severe obstruction. Against the background of the treatment, in the group of children who underwent surgical treatment followed by pharyngeal probiotic irrigation, an increase in IFN-γ content was recorded in combination with a decrease in IL-10, which can be interpreted as activation of the body's natural forces in response to therapeutic measures. A decrease in VEGF indicates an inhibition of tonsillar hypertrophy. The addition of probiotics to food can offset the lack of immune response caused by surgery.
Keywords: preschoolers, chronic adenoiditis, adenoidectomy, probiotic drugs, immune status
There is no conflict of interest.
Contact information of the author responsible for correspondence:
Valeria E. Menshchikova
vaidurova_valerya@mail.ru
Received 11.11.2025
For citation: Shajmardanov A.T., Bajburina G.A., Shajmardanov T.N., Kamilov F.H. Iodine deficiency and thyroid status in patients with chronic generalized periodontitis living in an area endemic for iodine deficiency. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2026, Vol. 23, no. 1, pp. 51–63. DOI: 10.22138/2500-0918-2026-23-1-51-63 (In Russ)
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Authors
Aleksandr O. Izumov
FSBEI HE NSMU MOH Russia
Candidate of Medical Sciences, Associate Professor, Head of the Department of Pediatric Dentistry
izumovao@yandex.ru
ORCID ID: 0000-0002-1223-1995
Novosibirsk, Russian Federation
Tatyana I. Ryabichenko
Federal State Budgetary Scientific Institution «Federal Research Center for Fundamental and Translational Medicine» (FRC FTM)
Doctor of Medical Sciences, Leading Researcher at the Laboratory of Immunology at the Research Institute of Experimental and Clinical Medicine
2925871@mail.ru.
ORCID ID: 0000-0002-0990-0078.
Novosibirsk, Russian Federation
Olga O. Obukhova
Federal State Budgetary Scientific Institution «Federal Research Center for Fundamental and Translational Medicine» (FRC FTM)
Doctor of Medical Sciences, Head of the Laboratory of Immunology at the Research Institute of Experimental and Clinical Medicine
trio188@yandex.ru
ORCID ID: 0000-0002-9834-1799
Novosibirsk, Russian Federation
Anastasiya E. Karavozova
FSBEI HE NSMU MOH Russia
Resident for 2 years of study in the specialty «Pediatrics» of the Department of Propaedeutics of Childhood Diseases
nastya_vae100@mail.ru
ORCID ID: 0009-0006-4496-0435
Novosibirsk, Russian Federation
Valeria E. Menshchikova
FSBEI HE NSMU MOH Russia
Postgraduate student of 2 years of study in the specialty «Pediatrics» of the Department of Propaedeutics of childhood Diseases
vaidurova_valerya@mail.ru
ORCID ID: 0009-0007-1119-7258
Novosibirsk, Russian Federation
Tatyana V. Kartseva
FSBEI HE NSMU MOH Russia
Doctor of Medical Sciences, Associate Professor, Head of the Department of Propaedeutics of Childhood Diseases, Chief freelance Pediatrician of the Ministry of Health of the Novosibirsk region
kartseva-t@mail.ru
ORCID ID: 0000-0001-7007-1996
Novosibirsk, Russian Federation
Vera G. Selyatitskaya
Federal State Budgetary Scientific Institution «Federal Research Center for Fundamental and Translational Medicine» (FRC FTM)
Doctor of Biological Sciences, Professor, Director of the Research Institute of Experimental and Clinical Medicine
vgselyatitskaya@frcftm.ru
ORCID ID: 0000-0003-4534-7289
Novosibirsk, Russian Federation