OLIGOPEPTIDES AS BIOCHEMICALLY SIGNIFICANT MOLECULES
DOI: 10.22138/2500-0918-2021-18-2-138-146
Yu.V. Boldyreva, I.A. Lebedev, E.V. Zakharchuk,
D.F. Garaev, S.V. Adamchuk, A.M. Smilyanin
Tyumen State Medical University, Tyumen, Russian Federation
Abstract. Peptides are a class of organic substances consisting of two or more amino acid residues connected to each other by peptide bonds —C(O)NH—. Peptides were first mentioned in 1900 by the German organic chemist G. E. Fischer. He assumed that peptides consist of a chain of amino acids connected by a certain type of bond. In 1902, he was able to prove the presence of a peptide bond, and by 1905 he had developed a general method that allows synthesizing peptides in the laboratory.
Friedrich Engels said the most succinctly about proteins: «Life is a way of existence of protein bodies…». It follows from this that if there are protein molecules, there is an organism’s life and, conversely, there are no proteins — the organism is not viable. Probably, this fact served as an incentive for further study of peptides. So, in the middle of the last century, an opinion appeared among scientists about a new class of chemically active substances-cytomedins (biologically active peptides, regulatory peptides, peptide bioregulators (PB)). These molecules will be discussed in this paper.
Keywords: oligopeptides, peptides, proteins, cytamines, bioregulators
There is no conflict of interest.
Contact details of the corresponding author:
Ilya A. Lebedev
lebedef@inbox.ru
Received 03.06.2021
For citation:
Boldyreva Yu.V., Lebedev I.A., Zakharchuk E.V., Garaev D.F., Adamchuk S.V., Smilyanin A.M. Oligopeptides as biochemically significant molecules. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2021, Vol. 18, no. 2, pp. __–__. DOI: 10.22138/2500-0918-2021-18-2-__-__ (In Russ)
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Authors
Yulia V. Boldyreva
Tyumen State Medical University
PhD
54 Odesskaya street Tyumen Russian Federation 625023
ORCID: 0000-0002-3276-7615
eLibrary SPIN: 1449-4485
tgma.06@mail.ru
Ilya A. Lebedev
Tyumen State Medical University
MD
54 Odesskaya street Tyumen Russian Federation 625023
ORCID: 0000-0001-5405-7182
eLibrary SPIN: 6155-1308
lebedef@inbox.ru
Ekaterina V. Zakharchuk
Tyumen State Medical University
Assistant
54 Odesskaya street Tyumen Russian Federation 625023
ORCID: 0000-0002-1317-5219
Javid F. Garaev
Tyumen State Medical University
Student of the Faculty of Dentistry
54 Odesskaya street Tyumen Russian Federation 625023
Sofia V. Adamchuk
Tyumen State Medical University
Student of the Faculty of Pediatrics
54 Odesskaya street Tyumen Russian Federation 625023
Arthur M. Smilyanin
Tyumen State Medical University
54 Odesskaya street Tyumen Russian Federation 625023
smilyanin@mail.ru
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)