EXPERIMENTAL METHOD OF REPLACEMENT OSTEOCHONDRAL DEFECTS OF THE HYALINE CARTILAGE OF THE LARGE JOINTS (FIRST RESULTS)
DOI: 10.22138/2500-0918-2019-16-1-50-56
G.A. Airapetov
Stavropol State Medical University, Stavropol, Russian Federation
Abstract. Disease and injury of the articular cartilage of large joints is an actual problem in orthopedics. Surgical interventions for replacement of the defect continue to develop actively.
The purpose is to improve the results of treatment of patients with defects of hyaline cartilage of large joints. Methods. A prospective study was conducted on experimental animals in an amount of 30, whose age was from 18 to 36 month, weight was from 20 to 30 kg. All animals are divided into 3 groups of 10 individuals, depending on the method of replenishment of the joint defect. In all groups, a full-thickness defect of the articular cartilage was performed to a subchondral bone 4.5 mm in diameter on the loaded surface of the inner condyle of the thigh. In our method reconstraction of osteo-chondral defects is used not only collagen matrix, but also autologous resources of the organism. Results. Fragments were examined visually after 1 month, evaluating the nature of the edges of the articular cartilage defect, the condition of its blood filling, the degree of closure of the defect by the emerging fibrous-cartilaginous layer. The best results are shown in group number 3, where the osteo-chondral defects are replaced to 2\3 macroscopically and microscopically managed to trace the architectonics of the newly formed hyaline-like tissue, which indicates good early results of the application of the described method. Conclusion. The use of the proposed method of treatment of osteochondral defects of the knee joint showed good macro-and microscopic results in the early stages. It is necessary to further research the behavior of the regenerate.
Keywords: osteo-chondral defects, membrane for regeneration, experiment, arthroplasty, replacement of the defect
There is no conflict of interest.
Contact details of the corresponding author:
Georgiy A. Airapetov
AirapetovGA@yandex.ru
Received 17.12.2018
For citation:
Airapetov G.A. Experimental method of replacement osteochondral defects of the hyaline cartilage of the large joints (First Results). Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 1, pp. 50–56. DOI: 10.22138/2500-0918-2019-16-1-50-56 (In Russ)
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Author
Georgiy A. Airapetov
Stavropol State Medical University
Cand. Sci. (Med.), Associate Professor, Department of Traumatology and Orthopedics
AirapetovGA@yandex.ru
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)