Features cytokine profile with traumatic intracranial hema-tomas with different outcome

Kravtsov Y. I., Kravtsova E. Y., Shevchenko K. V.

Perm state medical University named after academician
E. A. Wagner, Perm, Russian Federation

Abstract.
The analysis of the cytokine profile in the dynamics of 40 patients with different outcome of traumatic intracranial hematomas. It is established that in case of death traumatic intracranial hematomas on the deterioration of the General condition of the victims revealed a decrease in the concentration of IL-1β and a significant increase in the content of IL-6 and IL-10, which can be considered as an unfavorable prognostic signs of injury. The imbalance in cytokines directly indicates the stress and disruption of the regulatory mechanisms of the organism from the hypothalamic-pituitary-adrenal system.

Key words:
Traumatic intracranial hematoma, cytokines, the hypothalamic-pituitary-adrenal system

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Authors
Kravtsov Yury I.
MD, Professor, head. department of neurology
Kravtsova Elena Yu. 
MD, Professor of the department of neurology faculty and staff
Shevchenko Kirill V.
MD, Professor of the department of forensic medicine.

Perm state medical University named after academician E. A. Wagner
St. Petropavlovskaja, 26, Perm, 614000, Russian Federation
E-mail: rector@psma.ru