Effects of Nitric Oxide Donor Sin-1 on the Hemostasis in Physiological Pregnancy In Vitro
Klycheva M.M., Nazarov S.B., Kuz’menko G.N., Sitnikova O.G., Popova I.G.
State Research Institute of Maternite and Childhood, Ivanovo, Russian Federation
Abstract. Was a comparative characterization of the coagulation process under the influence of nitric oxide donator Sin-1 in pregnant and nonpregnant women by thromboelastography and platelet aggregation. On changes in the coagulation system was judged by comparison indicators thromboelastogram platelet rich plasma from blood plasma with Sin-1. This study found that during pregnancy reduced platelet sensitivity to nitric oxide. Found that during pregnancy reduced platelet sensitivity to nitric oxide, reduced activation time R and the angle α is increased under the influence of Sin-1 during pregnancy.
Key words: nitric oxide, platelet aggregation, thromboelastography, pregnancy.
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Authors
Klycheva Mayya M., maya_m_k@mail.ru
State Research Institute of Maternite and Childhood
junior researcher of clinical biochemistry and genetics
153045, Russian Federation, g. Ivanovo, ul. Pobedy, d. 20
Nazarov Sergey B., ivniimid@inbox.ru
Professor, Doctor of medical sciences, deputy director for science
Kuz'menko Galina N., ivniimid@inbox.ru
Doctor of medical sciences, leading researcher of clinical biochemistry and genetics
Sitnikova Ol'ga G., ivniimid@inbox.ru
Candidate of Biological Sciences, senior researcher of clinical biochemistry and genetics
Popova Irina G., ivniimid@inbox.ru
Candidate of medical Sciences, Researcher, Laboratory of Clinical Biochemistry and Genetics