НIV-Infection and Pregnancy. Сurrent Algorithms Prevent Vertical Transmission of HIV
L.D. Belotserkovtseva, L.V. Kovalenko, N.A. Tefnants, A.E. Kasparovа
pp. 75-83
Medical Institute Surgut State University, Department of Obstetrics and Gynecology, Surgut, Russian Federation
DOI: 10.22138/2500-0918-2016-14-2-75-83
Abstract. Surgut City in 2014 had a high prevalence of HIV — 1350.5 per 100 thousand population. Since 2007, due to changes in the regulatory framework for the prevention of vertical transmission of HIV we analyzed pregnancy outcomes in 193 women over the period 2001-2006 (retrospective research) and 499 women for the period 2007-2013 (prospective analysis). It is shown that carrying of pregnancy in women with HIV takes place in the context of high levels of specific infections, and is associated with the development of placental disorders (33.3% and 41.7% of pregnant women), premature birth (16.7% and 25.0% women, p <0,01) and the frequent transfer of newborns in the NICU — 33.3% and 25.0%, which is 2.7 and 7.7 times more children without HIV. The high degree of completeness of the implementation of the regional Protocol vertical HIV (antiretroviral prophylaxis / therapy and caesarean section without regard to viral load 38 weeks of pregnancy) influenced cha-simplicity of HIV transmission to the newborn and to minimize the risk of HIV infection of the child (0.0% 1.0%, respectively).
Keywords: HIV infection; pregnancy; vertical transmission; prevention; cesarean section
REFERENCES
1. Afonina L.Yu., Voronin E.E., Fomin Yu.A., Primenenie antiretrovi-rusnykh preparatov v komplekse mer, napravlennykh na profilaktiku pere-dachi VICh ot materi rebenku. Natsional'nye klinicheskie rekomendatsii. M. 2013. 8 p.
2. Taylor G. British HIV Association guidelines for the management of HIV infection in pregnant women 2012. G.Taylor, P. Clayden, J. Dhar, et al. Brit-ish HIV Association. 2012. 48 p.
3. Federal'nyy nauchno-metodicheskiy tsentr po profilaktike i bor'be so SPIDom. – M. — 2014. — URL: http://www.hivrussia.ru/
4. Battegay M. Slinical management and treatment of HIV-infected adults in Europe. M. Battegay, F. Mulcahy, et al. EACS Guidelines, Version 7.0, Octo-ber 2013. 49 p.
5. Belotserkovtseva L.D., Kasparova A.E., Kovalenko L.V., Mordovina I.I. Perinatal'nye infektsii: nastoyashchiy vzglyad na problemu. Sovremen-nye metody profilaktiki vertikal'nogo puti peredachi VICh: Uchebnoe po-sobie. Izd. SurGU. – 2008. 96 p.
6. Afonina L.Yu., Voronin E.E., Fomin Yu.A. Klinicheskie rekomendatsii po profilaktike peredachi VICh ot materi k rebenku. M. 2009. 49 p.
7. Afonina L.Yu., Voronin E.E., Fomin Yu.A.i dr. Primenenie anti-retrovirusnykh preparatov v komplekse mer, napravlennykh na profilakti-ku peredachi VICh ot materi rebenku. Natsional'nye klinicheskie rekomen-datsii. M. 2014. pp. 8-29.
8. Vartapetova N.V., Karpushkina A.V., Protopopova N.V., Odareeva E.V. Profilaktika vertikal'noy peredachi VICh ot materi rebenku: Uchebno-metodicheskoe posobie. IZS. M. 2011. 20 p.
9. Pokrovskiy V.V., Yurin O.G., Kravchenko A.V. i dr. Protokoly dis-pansernogo nablyudeniya i lecheniya bol'nykh VICh-infektsiey. Epidemiolo-giya i infektsionnye bolezni. Aktual'nye voprosy. 2012. No. 6. P. 6.
10. World Health Organization. Strategies approaches to the prevention of HIV infection in infants: report of a WHO meeting, Morges (Switzerland) 2002. World Health Organization, 2003. Available at: URL: http://www.who.int/hiv/pub/mtct/en/ StrategicApproachesE.pdf. Accessed June 21, 2010.
11. De Ryuyter A. Vedenie VICh-infektsii u beremennykh zhenshchin. — 2008. -URL: http://www.bhiva.org/PregnantWomen2008.aspx.
12. Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for use of antiretroviral drugs in pregnant HIV-1- infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. May 24, 2010. p. 1–117. Available at: URL: http:// aidsinfo.nih.gov/ContentFiles/PerinatalGL.pdf. Ac-cessed June 21. 2010.
13. World Health Organization. Rapid advice: use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants – November 2009. Geneva (Switzerland): World Health Organization, 2009. Available at: URL: http:// www.who.int/hiv/pub/mtct/rapid_advice_mtct.pdf. Accessed June 21 — 2010.
14. Profilaktika peredachi VICh ot materi rebenku. Optimizatsiya klini-cheskoy taktiki i effektivnye metody likvidatsii novykh sluchaev VICh-infektsii u detey. Klinicheskiy protokol dlya evropeyskogo regiona VOZ (obnovlennaya versiya 2012 g.) Vsemirnaya organizatsiya zdravookhraneniya. 2012. pp. 8-29.
15. URL: http://www.who.int/hiv/pub/vct/hiv_testing_counseling/ru/index.html
16. Nielsen-Saines K et al. phase III randomized trial of the safety and efficacy of 3 neonatal ARV regimens for prevention of intrapartum HIV_1 transmission: NICHD HPTN 040/PACTG 1043. 18-th Conference on Retroviruses and Oppor-tunistic Infections, Boston, 27 February–2 March 2011, Abstract no. 124LB.
17. Sadovnikova V.N., Vartapetova N.V., Karpushkina A.V., Protopopova N.V. Organizatsionnye aspekty profilaktiki peredachi VICh-infektsii ot materi k rebenku. Sibirskiy meditsinskiy zhurnal. 2008. No. 3. 68 p.
18. United Kingdom National Guidelines for HIV Testing, 2008. — London, Brit-ish HIV Association. 2008. p. 48.
19. Vartapetova N.V., Karpushkina A.V., Epoyan T.A., Aktual'nye problemy profilaktiki peredachi VICh ot materi rebenku. M. 2010. pp. 5-44.
Authors:
Belotserkovtseva Larisa D.
Medical Institute Surgut State University
Head Department of Obstetrics, Gynecology and Perinatology Medical Institute. Surgut State University, chief physician of the Surgut Clinical Perinatal Center, MD, Professor, Honored Doctor of the Russian Federation,
str. Gubkin 1, Surgut, Tyumen Region, 628400 Russian Federation
info@surgut-kpc.ru
Kovalenko Ludmila V.
Medical Institute Surgut State University
Director of the Institute of Medicine, Surgut State University, MD, Professor
Lenin Avenue 1. Surgut, Tyumen Region, 628400 Russian Federation
lvkhome@yandex.ru
Tefnants Nver A.
Surgut clinical perinatal center
Obstetrician-gynecologist Surgut clinical perinatal center. Student of midwifery, gynecology and perinatology. Medical Institute. Surgut State University
str. 30 Let Pobedy, 50-159 Surgut, Tyumen Region, 628400 Russian Federation
romeo-kappuleti@yandex.ru
Kasparov Angelica E.
Medical Institute Surgut State University
Associate Professor of Obstetrics, Gynecology and Perinatology Medical Institute. Surgut State University, MD
str. Gubkin 1, Surgut, Tyumen Region, 628400 Russian Federation
anzkasparova@yandex.ru
Receivd – 09.02.2016
For citation:
Belotserkovtseva L.D., Kovalenko L.V., Tefnants N.A., Kasparovа A.E. HIV-infection and Pregnancy. Current Algorithms Prevent Vertical Transmission of HIV [Osobennosti kompleksnogo podkhoda k vedeniyu beremennykh s VICH. Metody profilaktiki vertical‘noj peredachi infektsii] Vestnik uralskoi meditsinskoi akad-emicheskoi nauki – Vestn. Ural. Med. Akad. Nauki. 2016, no. 2, pp. 75-83. DOI: 10.22138/2500-0918-2016-14-2-75-83 [In Russ.]