Features of Retinal Damage in Experimental Diabetes Mellitus
Smirnyh S.E., Chereshneva M.V., Danilova I.G.
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences,
Yekaterinburg, Russian Federation
Abstract. In animal model has been shown that in the early stages of diabetes retinal damage are developed and manifested in the loss of the integrity of the pigment cells and blood vessels of the retina and the choroid, which are main structures of the blood-retinal barrier. There is a progression of degenerative processes in these tissues with increasing duration of diabetes.
Keywords: diabetes, retina, blood-retinal barrier
REFERENCES
1. Barber, A.О. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Progress in Neuro-Psychopharmacology and Biological Psychiatry 27 (2003) pp. 283-290.
2. Klaassen I. et al. Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions. Progress in retinal and Eye Research 34 (2013) pp. 19-48.
3. Garner A. Histopathology of diabetic retinopathy in man. Eye 7 (1993) 250-253.
4. Danilova I.G., Medvedeva S.Ju., Bulavinceva T.A. Gette I.F., Smirnyh S.E., Chereshneva M.V., Abidov M.T. The modulling influence of macrophages on recovery of structural changes of vascular tunic of eye in experimental diabetes. Ural Medicine Journal. — 2011 г. No. 01 (79). – pp. 49-53.
5. Medvedeva S.Ju., Bulavinceva T.S., Danilova I.G., Gette I.F., Sencov V.G. Toxic effect of alloxan in the dynamics of alloxan diabetes. Vestnik ural'skoj medicinskoj akademicheskoj nauki, 2012, №3, С.30–33
Authors
Smirnyh Svetlana E., s.smirnyh@yandex.ru
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
postgraduate student
620049, Russian Federation, Yekaterinburg, st. Pervomajskaja, 106
Chereshneva Margarita V., mchereshneva@mail.ru
MD, professor, chief researcher of the laboratory of immunophysiology and immunopharmacology
Danilova Irina G., ig-danilova@yandex.ru
Sc.D., Head of the Laboratory of Morphology and Physiology