PILOT STUDY OF PREVALENCE OF GASTROESOPHAGEAL REFLUX DISEASE IN PATIENTS WITH BRONCHIAL ASTHMA
DOI: 10.22138/2500-0918-2018-15-5-651-657
R.I. Akimenko, O.M. Khromtsova, I.B. Khlynov, T.A. Gitman
Ural State Medical University, Yekaterinburg, Russian Federation
Abstract. The aim — to assess the symptoms and gastroesophageal reflux disease risk factors frequency in patients with bronchial asthma based on current diagnostic criteria. Methods. An anonymous survey of 115 respondents without bronchial asthma randomly selected with the assistance of the yellow pages and 68 patients with bronchial asthma using the GERD-Q questionnaire and a questionnaire with data on sex, age, height, body weight, smoking and taking nonsteroidal anti-inflammatory drugs more than 1 time per week. Results. In patients with bronchial asthma, the symptoms of gastroesophageal reflux disease according to the GERD-Q questionnaire are more common on 19.5% than in respondents without bronchial asthma (p=0.002). Differences in such risk factors for gastroesophageal reflux disease as smoking and nonsteroidal anti-inflammatory drugs use in patients with bronchial asthma and gastroesophageal reflux disease and in respondents without bronchial asthma are not significant. Overweight and obesity in patients with bronchial asthma and symptoms of gastroesophageal reflux disease and are significantly more frequent (p=0.026).
Keywords: gastroesophageal reflux disease, bronchial asthma, risk factors, heartburn
There is no conflict of interest
Contact information of the author responsible for correspondence:
Regina I. Akimenko
khlynova-ri@yandex.ru
Received 08.11.2018
For citation:
Akimenko R.I., Khromtsova O.M., Khlynov I.B., Gitman T.A. Pilot study of prevalence of gastroesophageal reflux disease in patients with bronchial asthma. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 5, pp. 651–657. DOI: 10.22138/2500-0918-2018-15-5-651-657 (In Russ)
REFERENCES
1. El-Serag H.B., Sweet S., Winchester C.C., Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014; Vol. 63, (6): 871-880.
2. V.T. Ivashkin, I.V. Mayev, A.S. Trukhmanov., Ye.K. Baranskaya, О.B. Dronova, О.V. Zayratyants et al. Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological association. Ross z gastroenterol gepatol koloproktol. 2017; (27): 75-95. (in Russ).
3. Chikunova M.V., Khromtsova O.M., Khlynov I.B. Gender and age-specific characteristics of the prevalence of heartburn. Medicine: periodical educational edition of RSMU. 2016; (1): 33-38. (in Russ).
4. Ivashkin V.T. Brief guide of gastroenterology.М.: MEDpress-inform; 2001. (in Russ).
5. Shupelkova J.O., Ivashkin V.T. Gastroesophageal reflux disease: clinical and pharmacological aspects. Ross z gastroenterol gepatol koloproktol. 2002; Т.10, (4): 200-205. (in Russ).
6. Vakil N., van Zanden, Kahrilas P., Dent J., Jones R. The Monreal definition and classification of gastroesophageal reflux disease: A global evidence-based consensus. Am. J. Gastroenterol. 2006; (101): 1900-1920.
7. Ruhl C.E., Everhart J.E. Respiratory complications of gastroesophageal reflux disease in a prospective population-based study. Gastroenterol. 1999; Vol. 115: 92.
8. Barlamov P.N. Gastroesophageal reflux in bronchial asthma. Pulmonology. 2003; (2): 90-93. (in Russ).
9. Burkov S.G., Alekseeva E.P., Jurenev G.P., Arutjunov A.G. Clinics, diagnostics and treatment of gastroesophageal reflux disease associated with bronchial asthma. Farmateka. 2007; (6): 38–43. (in Russ).
10. Kirillov M.M., Shapovalova T.T., Shashina M.M. Extrapulmonary pathology in patients with bronchial asthma (clinical and morphological aspects). Pulmonology. 2002; (5): 87–92. (in Russ).
11. Vincent D., Cohen-Jonathan A.M., Leront J. et al. Gastro-esophageal reflux prevalence and relationship with bronchial reactivity in asthma. Eur. Respir. J. 1997; Vol.10, (10): 2255–2259.
12. Bejtuganova I.M., Chuchalin A.G. Reflux-induced bronchial asthma. RMJ. – 1998; Т.17, (6): 1102–1108. (in Russ).
13. Hisel T.M., Bielefeldt K., Joss J.D. Asthma and gastroesophageal reflux. J. Am. Osteopath Assooc. 1999; Vol. 99, 10 (Suppl. 1): P. 9–13.
14. Rodriguez S.O., Suarez J.R., Morales S.O. et al. Gastroesophageal reflux and allergic bronchial asthma. Controlled study. Rev. Alerg. Mex. 1999; Vol.46, (2): 38–40.
15. Gatto G., Peri V. Guttitta G. Gastroesophageal reflux symptoms and asthma severity: 7th united. Eur. Gastroenterol Week, Roma. – Italy. (Abstract P0028). – 1999.
16. Medvedev A.V., Shmelev E.I. Clinic and treatment of bronchial asthma, combined with gastroesophageal reflux. Pulmonology. 2002; Т.12, (2): 22–27. (in Russ).
17. Pleshko R.I., Suhodolo I.V., Ogorodova L.M. Morphological and functional aspects of conjugation of asthma and gastroesophageal reflux. Bulletin of siberian medicine. 2005; (4): 54.–59. (in Russ).
18. Roshhina T.V. Gastroesophageal reflux disease in patients with bronchial asthma: diss. Moscow; 2002. (in Russ).
19. Nakase H., Itani T., Mimura J. Relationship between asthma and gastro-esophageal reflux: significance of endoscopic grade on reflux-esophagitis in adult asthmatics. J. Gastroenter. Hepatol. 1999; Vol. 14: 715–722.
20. Extrom T., Tibbling L. Gastroesophageal reflux and triggering of brionchial asthma: a negative report. Eur. J. Resp. Dis.1987; Vol.71, (3): 177–180.
21. Field S.K., Evans J.A., Price L.M. The effect of acid perfusion of the esophagus on ventilation and respiratory sensation. Am. J. Respir. Crit. Care Med. 1998; Vol. 157, (4): 1058–1062.
22. Wesseling G., Brummer R.J. Gastric asthma? No change in respiratory impedance during intraesophageal acidification in adult asthmatics. Chest.1993; Vol. 104, (6): 1733 – 1736.
23. Dent J. Review article: from 1906 to 2006 – a century of major evolution of understanding of gastrooesophageal reflux disease. Aliment. Pharmacol. Ther. 2006; (24):1269–1281.
24. Rosaida MS, Goh KL. Gastro-oesophageal reflux disease, reflux oesophagitis and non-erosive reflux disease in a multiracial Asian population: a prospective, endoscopy based study. Eur J Gastroenterol Hepatol 2004; 16: 495–501.
25. Boeckxstaens G., El-Serag H.B., Smout A.J., Kahrilas P.J. Symptomatic reflux disease: the present, the past and the future. Gut. 2014; Vol. 63, (7):1185-1193.
26. Wu J.C., Mui P.M., Cheung CM. et al. Obesity is associated with increased transient lower esophageal sphincter relaxation. Digestion. 2007; Vol. 132, (3): 883-889.
27. Ivashkin V.T., Truhmanov A.S. The evolution of ideas about the role of disorders of the motor function of the esophagus in the pathogenesis of gastroesophageal reflux disease. Ross z gastroenterol gepatol koloproktol. 2010; Т.20, (2):13-19. (in Russ).
28. Nilsson M, Johnsen R, Ye W, et al. Lifestyle related risk factors in the aetiology of gastro-oesophageal reflux. Gut. 2004; (53):1730-1735.
29. Ruszneiewski P., Soufflet C., Barthelemy P.Nonsteroidal anti-inflammatory drug use as a risk factor for gastro-oesophageal reflux disease: an observational study. Alimentary Pharmacology & Therapeutics, 2008 (28): 1134-1139.
30. Laitman J.T., Reidenberg J.S. The human aerodigestive tract and gastroesophageal reflux: an evolutionary perspective. Am. J. Medicine.1997; Vol. 103, (5A): 2–8.
31. Mansfield L.E., Stein M.R. Gastroesophageal reflux and asthma: a possible reflux mechanism. Ann. Allergy. 1978; Vol. 41, (4): 224–226.
32. Mendelsohn C.L. The aspiration of stomach contents into the lungs during obstetric anesthesia. Am. J. Obstet. Gynec. 1946; Vol. 52, (2): 191–195.
33. Singh, Siddharth et al. Central Adiposity Is Associated With Increased Risk of Esophageal Inflammation, Metaplasia, and Adenocarcinoma: A Systematic Review and Meta-analysis. Clinical Gastroenterology and Hepatology. 2013; Vol. 11, Issue 11: 1399 — 1412.
34. El-Serag, Hashem B. et al. Gastroesophageal reflux among different racial groups in the United States. Gastroenterology. 2004; Vol. 126, Issue 7: 1692 – 1699.
Authors
Regina I. Akimenko
Assistant of Intermediate Therapy and Geriatrics Department
khlynova-ri@yandex.ru
Oksana M. Khromtsova
Dr. Sci. (Med.), Assistant Professor, Head of Intermediate Therapy and Geriatrics Department
oksanamed7@yandex.ru
Igor B. Khlinov
Dr. Sci. (Med.), Assistant Professor of Intermediate Therapy and Geriatrics Department
hlinov.doc@yandex.ru
Tatyana A. Gitman
Student
cardinalis14@gmail.com
Ural State Medical University
Russian Federation, 620028, Yekaterinburg, 3 Repin St.
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