Characteristics of Functional Geometry of the Left Ventricle in Patients with Ischemic Heart Disease and Dilated Cardiomyopathy
Chumarnaya T.V., Alueva J.S., Kochmasheva V.V., Sukhareva S.V., Mikhailov S.P., Solovyova O.E.
Institute of Immunology and Physiology of RAS, Yekaterinburg Regional Clinical Hospital No1, Ural Federal University, Yekaterinburg, Russian Federation
Abstract. Functional geometry of left ventricle (FGLV) refers to the dynamical change in the ventricular shape during contraction and relaxation. It has been shown that FGLV significantly contributes to the regulation of contractility and cardiac pump function in health and disease. We determined abnormalities of FGLV in patients with ischemic heart disease and dilated cardiomyopathy before and after resynchronization therapy. FGLV abnormalities are early predictors of LV pump function disturbances. FGLV recovery is accompanied with an increase in LV pump function.
Keywords: functional geometry of left ventricle
REFERENCES
1. Markhasin V.S., Solov'eva O., Chumarnaya T.V., Sukhareva S.V. Problem of heterogeneity of myocardial. Russian Journal of Physiology. V. 95. N.9. p. 919-943. 2009
2. T.V. Chumarnaya, O. Solovyova, S.V. Sukhareva, T.A. Vargina, V.S. Markhasin Spatio-Temporal Heterogeneity of Human Left Ventricle Contractions in Norm and Under Ischemic Heart Disease. Russian Journal of Physiology. V. 94. N.11. P. 1217-1239. 2008
3. Markhasin V.S., Glasman A.A., Chestuhin V.V. Contribution of segmental heterogeneity of myocard of left ventricular wall in its contractile and pump function. Russian Journal of Physiology. V. 80. N.4. P. 72-80. 1994
4. Di Donato M., Dabic P., Castelvecchio S. Left ventricular geometry in normal and post-anterior myocardial infarction. Europ. J. Cardiothorac. Surg. 2006. V. 29. Suppl. 1.P. 225–230.
5. DA Kass, TA Traill, M Keating, PI Altieri and WL Maughan. Abnormalities of dynamic ventricular shape change in patients with aortic and mitral valvular regurgitation: assessment by Fourier shape analysis and global geometric indexes. Circ. Res. 1988.V. 62. № 1. P. 127–138.
Authors
Chumarnaya Tatiana V., t.chumarnaya @ iip.uran.ru
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences (IIP UB RAS), PhD, Researcher. 620041, Yekaterinburg, Pervomayskaya street, 106
Alueva Julia S.
IIP UB RAS. Junior Researcher
Yekaterinburg Regional Clinical Hospital No1 (YRCH#1) doctor of functional diagnostics 620050, Yekaterinburg, Volgogradskaya street, 185
Kochmasheva Valentina V.
YRCH No1, MD, head of the department of functional diagnostics
Mikhailov Sergey P.
YRCH№1, MD, head of the Department arrhythmology
Sukhareva Svetlana V.
YRCH №1, doctor of functional diagnostics
Solovyova Olga E., o.solovyova@iip.uran.ru
IIP UB RAS Prof., Head of the Laboratory of Mathematical Physiology
Ural Federal University 620002, Yekaterinburg, Mira street, 19