ROLE OF BIOLOGICAL CLOCK MALFUNCTION IN THE PATHOGENESIS OF DIABETES MELLITUS

DOI: 10.22138/2500-0918-2023-20-3-5-17

Yu. V. Bykov

Federal State Budgetary Educational Institution “Stavropol State Medical University”
of the Ministry of Health of the Russian Federation, Stavropol, Russian Federation;
State budgetary healthcare institution of the Stavropol Territory “City Children’s Clinical Hospital named after G.K. Filippsky», Stavropol, Russian Federation

Abstract. Purpose. This paper provides a review of biological clock (BC) malfunction as a possible pathophysiological mechanism underlying the development of type 1 and 2 diabetes mellitus (DM). Objective of the review. A total of 69 scientific papers were found using the Cochrane Library, PubMed, eLibrary.ru and Medscape, and analyzed. The search covered the period from 2012 to 2023 and used the combination of the following keywords: “diabetes mellitus”, “biological clock”, “melatonin”. Results. It covers the main physiological aspects of BC operation and their contribution to the maintenance of the body’s homeostasis. Also discussed are issues related to BC-mediated regulation of glucose and insulin levels. Arguments are provided to corroborate the involvement of BC malfunction in the development of DM through biological rhythm desynchronization, activation of mitochondrial dysfunction, and oxidative stress. Another point of discussion is disrupted melatonin synthesis as a marker of BC malfunction and as a possible trigger of the development of DM. Conclusion. The theory of the involvement of BC malfunction in DM pathogenesis is up-to-date and supported by scientific evidence and therefore needs to be researched and developed further.

Keywords: diabetes mellitus, biological clock, melatonin

There is no conflict of interest.
Contact details of the corresponding author:
Yuri V. Bykov
yubykov@gmail.com
Received 31.08.2023
For citation:
Bykov Yu. V. Role of biological clock malfunction in the pathogenesis of diabetes mellitus. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2023, Vol. 20, no. 3, pp. 5–17. DOI: 10.22138/2500-0918-2023-20-3-5-17 (In Russ)

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Author
Yuri V. Bykov
Federal State Budgetary Educational Institution “Stavropol State Medical University” of the Ministry of Health of the Russian Federation;
State budgetary healthcare institution of the Stavropol Territory “City Children’s Clinical Hospital named after G.K. Filippsky
Candidate of Medical Sciences, Docent of the Department of Anesthesiology and Intensive Care with a course of additional professional education, anesthesiologist-reanimatologist
yubykov@gmail.com
ORCID ID: https://orcid.org/0000-0003-4705-3823
Stavropol, Russian Federation