ORGAN AND TISSUE DAMAGE FROM ACETAMINOPHEN POISONING
DOI: 10.22138/2500-0918-2024-21-4-499-507
A.I. Zudova, E.A. Mukhlynina, L.V. Solomatina
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation
Abstract. The number of intentional and unintentional acetaminophen (paracetamol) poisonings increases every year. The literature mainly presents data on liver damage due to acute toxic effects of the drug. However, there is little information on damage to other organs and systems, such as the brain, etc. The aim of the study was to determine morphometric parameters in the liver, kidney, and lung tissue of experimental animals poisoned with acetaminophen. Materials and methods. We used 10-week-old C57Bl/6 male mice. The experimental group was administered acetaminophen solution (14 mg/ml, 600 mg/kg body weight), and the control group was administered saline. Six hours after administration of the drug, the animals were withdrawn from the experiment, their internal organs were taken, and their histological analysis was performed. Results. The tissue of the organs showed signs of toxic damage caused by acetaminophen. A statistically significant decrease in the nuclear-cytoplasmic ratio in hepatocytes, the area of glomeruli in the kidneys and an increase in the Bowman-Shumlyansky space are noted. At the same time, no statistically significant differences in the area of the renal corpuscle and the total area of the alveoli and the total area of the interalveolar septum and alveolar epithelium were found. Conclusion. 6 hours after administration of a half-year dose of acetaminophen to C57Bl/6 mice, signs of toxic damage to internal organs are noted, manifested in a violation of the activity of the microcirculatory bed.
Keywords: acetaminophen, paracetamol, poisoning, liver, kidney, lungs, damage
There is no conflict of interest.
Contact details of the corresponding author:
Alevtina I. Zudova
tina.zudova@mail.ru
Received: 01.09.2024
For citation: Zudova A.I., Mukhlynina E.A., Solomatina L.V. Organ and tissue damage from acetaminophen poisoning. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2024, Vol. 21, no. 4, pp. 499–507. DOI: 10.22138/2500-0918-2024-21-4-499-507 (In Russ)
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Auhtors
Alevtina I. Zudova
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences (IIP UB RAS)
Junior researcher (Laboratory of Inflammation Immunology)
Yekaterinburg, Russian Federation
tina.zudova@mail.ru
Elena A. Mukhlynina
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences (IIP UB RAS)
PhD, senior researcher (Laboratory of morphology and biochemistry)
Yekaterinburg, Russian Federation
elena.mukhlynina@yandex.ru
Liliya V. Solomatina
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences (IIP UB RAS)
PhD, senior researcher (Laboratory of Inflammation Immunology)
Yekaterinburg, Russian Federation
slv10@list.ru