Early Changes of Hemostasis in Acute Massive Blood Loss
Ermolaeva E.N., Krivokhizhina L.V., Nesterov M.I., Kantyukov S.A., Surina-Marysheva E.F.
South Ural State Medical University (SUSMU), Ural State University of Physical Culture, Chelyabinsk, Russian Federation
Abstract. In experiments on rats found that after 30 minutes of acute massive blood loss of 30–40% of EBV occurs launch coagulation hemostasis: significantly increased — recalcification time 3,2-fold, activated partial thromboplastin time, prothrombin and thrombin clotting time 1,4-fold; fibrinogen concentration increased by 12% compared with the control. At the same functional parameters of platelet hemostasis do not go beyond the normal range. Simultaneously activated and system antigemostaza as anticoagulant (antithrombin III activity increased 1,5-fold) and the fibrinolytic (fibrin degradation products content increased 3-fold compared to control). This early selective activation of the coagulation system prevents excessive launch of thrombus in response to blood loss and subsequent development of thrombogenic complications.
Keywords: acute hemorrhage, hemostasis, hypercoagulation, fibrinolysis
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Authors
Ermolaeva Elena N., ermen33@mail.ru
South Ural State Medical University (SUSMU), MD, PhD
Russian Federation, 454092, Chelyabinsk, Vorovskogo st., 64
Krivohizhina Lyudmila V.
Head of Department, MD, PhD
Nesterov Maksim I.
graduate student
Kantyukov Salavat A.
MD, PhD, associate professor of Department of Pathological Physiology
Surina-Marisheva Elena F.
Ural State University of Physical Culture, BD, PhD
Russian Federation, 454091, Chelyabinsk, Ordzhonikidze st., 1