Reactions of the Adaptive Immunity in Residents of the Far North
DOI: 10.22138/2500-0918-2018-15-2-285-290
O.S. Morozova, O.E. Philippova, T.Y. Shashkova
Federal Agency of scientific organizations (FANO of Russia) Federal state budget institution of science, Federal research center for integrated study of the Arctic named after academician N. P. Laverov, Russian Academy of Sciences, Arkhangelsk, Russian Federation
Abstract. Yamalo-Nenets Autonomous Okrug (YANAO) as a region geographically belonging to the regions of high latitudes, is a uncomfortable territory with intense natural and man-made pressure on the health of people, reflected in the pronounced stress of the adaptive systems of the body, creating a high risk of disruption or loss of health. Purpose of research. The aim of the study was to Reveal the peculiarities of the immune status in women aged 35–60 living in the Yamalo-Nenets Autonomous district of Nadym and Pinega settlement of the Arkhangelsk region. Materials and methods. In the period 2011–2015 conducted expeditions to the town of Nadym in Yamalo-Nenets Autonomous district and the settlement of Pinega, Arkhangelsk region. 82 women aged 35–60 years were examined. Immunological studies conducted in the laboratory of physiology of immunocompetent cells of the Institute of physiology of natural adaptations, VICKIE them. N.P. Laverov Russian Academy of Sciences, Arkhangelsk, Russia. The concentration of CD16+, CD25+, CD71+, CD95+, HLADR+ lymphocytes phenotypes was determined in peripheral blood; the absolute content of leukocytes and lymphocytes. Results. In women surveyed YANAO and POS Pinega Arkhangelsk region found the reduction in reserve capacity of the immune homeostasis due to the increased cytotoxic activity (CD16+) 57.50±1.88% and from of 56.09±1.77%, apoptosis (CD95+) from 37.50±1.52% and 37.77±1.45% of individuals, and the lack of the histocompatibility antigens class II (HLADR+), 20.00±1.11% and of 17.77±0.99% of women, respectively.
Key words: lymphocyte Phenotypes, leukocytes, North, adaptive immunity, immune responses
Received 09.04.2018
For citation:
Morozova O.S., Philippova O.E., Shashkova T.Y. Reactions of the Adaptive Immunity in Residents of the Far North. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 2, pp. 285–290. DOI: 10.22138/2500-0918-2018-15-2-285-290 (In Russ)
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Authors
Olga S. Morozova
Cand. Sci. (Biol.), Researcher
olia.morozow2011@yandex.ru
Oksana E. Filippova
Cand. Sci. (Biol.), Senior researcher
oxana_filippova_85@mail.ru
Elizaveta Y. Shashkova
Cand. Sci. (Biol.), Senior researcher
eli1255@yandex.ru
Federal Agency of scientific organizations (FANO of Russia) Federal state budget institution of science, Federal research center for integrated study of the Arctic named after academician N.P. Laverov, Russian Academy of Sciences, Institute of physiology of natural adaptations
Russian Federation, 163000, Arkhangelsk, Lomonosov Ave., 249
