Regulatory T-Cells in Diseases Associated with the Development of Inflammation
УДК 632.938
DOI: 10.22138/2500-0918-2019-16-4-450-456
A.V. Churov, E.K. Oleinik, A.A. Romanov
Institute of Biology of the Karelian Research Centre of the Russian Academy of Sciences (IB KarRC RAS), Petrozavodsk, Russian Federation;
State Budgetary Healthcare Institution «Republican Oncology Center», Petrozavodsk, Russian Federation
Abstract. The aim of the was to study the content of subpopulations of regulatory T cells (Treg) in diseases accompanied by the development of inflammation.Material and methods. We studied the subpopulation composition of regulatory T cells (Treg) in the peripheral blood of 20 patients with breast cancer and 17 patients with cerebrovascular disorders. The expression of Treg cell markers was analyzed by flow cytometry.Results. Patients with breast cancer and cerebrovascular disorders demonstrated elevated levels of CD4+ Treg subpopulations in peripheral blood. The level of Treg cells was the highest in the late stages (III-IV) of breast cancer and in patients with a chronic form of cerebrovascular disorders.Conclusion. The data obtained suggest that the quantitative indicators of some subpopulations of Treg cells can be used in comprehensive diagnosis of some inflammation-accompanied diseases.
Keywords: regulatory T cells, transcriptional factor FOXP3, breast cancer, cerebrovascular disorders
Received 25.09.2019
For citation: Churov A.V., Oleinik E.K., Romanov A.A. Regulatory T-cells in Diseases Associated with the Development of Inflammation. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 4, pp. 450–456. DOI: 10.22138/2500-0918-2019-16-4-450-456 (In Russ)
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Authors
Alexey V. Churov
Institute of Biology of the Karelian Research Centre of the Russian Academy of Sciences
Senior Researcher, Immunology Group, PhD (Biology)
11 Pushkinskaya St., 185014 Petrozavodsk, Republic of Karelia, Russian Federation
achurou@yandex.ru
Eugenia K. Oleinik
Institute of Biology of the Karelian Research Centre of the Russian Academy of Sciences
Head of Immunology Group, PhD (Biology)
11 Pushkinskaya St., 185014 Petrozavodsk, Republic of Karelia, Russian Federation
ole@krc.karelia.ru
Aleksander A. Romanov
Republican Oncology Centre
oncology surgeon
5 Lososinsky highway Petrozavodsk Republic of Karelia 185002 Russian Federation
tiffozi@mail.ru