Role of macrophages in the reparativny regeneration kidney

DOI: 10.22138/2500-0918-2016-14-4-17-22

I.G. Danilova, B.G. Yushkov, I.A. Kazakova, S.A. Brilliant, M.T. Abidov

Institute of medical cell technologies, Yekaterinburg, Russian Federation;
Institute of immunology and physiology of URO Russian Academy of Sciences, Yekaterinburg, Russian Federation;
Institute of immunopathology, Moscow, Russian Federation

Abstract. Reparative regeneration processes in kidney are accompanied by macrophage infiltration in the organ. Blocking of the macrophagal functional activity dramatically reduces the proliferative potential of the renal epithelium and the glomerular apparatus in the damaged kidney.

Key words: kidney, macrophages, regeneration

REFERENCES
1. Cao Q., Harris D.C., Wang Y. Macrophages in kidney injury, inflammation and fibrosis. Physiology. 2015. Vol. 30 (3). pp. 94-183. DOI: 10.1152/physiol.00046.2014.
2. Lee S., Huen S. et all. Distinct macrophage phenotypes contribute to kidney injury and repair. J. Am. Soc.Nephrol. 2010. Vol .22. pp. 317–326. DOI: 10.1681/ASN.2009060615.
3. Abidov M.T. Immunotropic activity tamerita [Immunotropnaya aktivnost' tamerita] Bulletin of Experimental Biology and Medicine [Byulleten' eksperimental'noy biologii i meditsiny].2002. No. 3. pp.11-19, (In Russ.).
4. Chazaud B. Macrophages: supportive cells for tissue repair and regeneration. Immunobiology. 2014. Vol. 219 (3). pp. 8-172. DOI: 10.1016/j.imbio.2013.09.001.
5. Huen S.C., Cantley L.G. Macrophage-mediated injury and repair after ischemic kidney injury. Pediatr. Nephrol. 2014. Vol. 30. pp. 199–209. DOI: 10.1186/s12967-016-0782-3.
6. Kim M.G., Boo C.S., KoY.S. et all. Depletion of kidney CD11c+ F4/80+ cells impair the recovery process in ischaemia reperfusion-induced acute kidney injury. Nephrol. Dial. Transplant. 2010. Vol. 25. pp. 2908–2921. DOI:10.1186/1471-2369-14-138.
7. Lin S.L., Li B., Rao S. et all. Macrophage Wnt7b is critical for kidney repair and regeneration Proc. Natl. Acad.Sci. USA. 2010. Vol. 107(9). pp. 9-4194. DOI: 10.1073/pnas.0912228107.
8. Matsumoto K., Nakamura T. Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases. Kidney Int. 2001. Vol. 59(6). pp. 38-2023. DOI: 10.1093/oxfordjournals.jbchem.a021283.
9. Rangel E.B., Gomes S.A. et al. C-kit (+) cells isolated from developing kidneys are a novel population of stem cells with regenerative potential. Stem. Cells. 2013. Vol. 8. pp. 56-1644.
10. Schmidt-Ott K.M., Chen X. et all. C-kit delineates a distinct domain of progenitors in the developing kidney. Dev. Biol. 2006. Vol. 299(1). pp. 49-238. DOI: 10.1016/j.ydbio.2006.07.026.
11. Stokman G., Stroo I., Claessen N. et al. Stem cell factor expression after renal ischemia promotes tubular epithelial survival. PLo. S. One. 2010. Vol. 5(12). pp.14-386. DOI: 10.1371/journal.pone.0014386.
12. Randall T.D., Weissman I.L. Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: resting stem cells or mystery population. Stem. Cells. 1998. Vol. 16(1). pp. 38-48.
13. Bengatta S., Arnould C., Letavernier E. et all. MMP9 and SCF protect from apoptosis in acute kidney injury. J. Am. Soc. Nephrol. 2009. Vol. 20(4). pp. 97-787. DOI:20/4/787 (pii)10.1681/ASN.2008050515.
14. Ren X., Hu B., Colletti L. Stem cell factor and its receptor, c-kit, are important for hepatocyte proliferation in wild-type and tumor necrosis factor receptor-1 knockout mice after 70% hepatectomy. Surgery. 2008. Vol. 143(6). pp. 790-802.
15. Tomislav J., Abidov M. et all. A Tetrahydrophthalazine Derivative «Sodium Nucleinate» Exerts a Potent Suppressive Effect upon LPS-Stimulated Mononuclear Cells in vitro and in vivo. Coll. Antropol. 2011. Vol. 35(4). pp. 1219–1223.
16. Eliniadi V.N., Anikeeva N.V., Maksimova N.A. Practical immunohistochemistry [Prakticheskaya immunogistokhimiya]. SPb. 2002. p.36, [In Russ].
17. Ekstrom K., Omar O., Graneli C. et all. Monocyte exosomes stimulate the osteogenic gene expression of mesenchymal stem cells. P.Los. 2013. Vol. 8. pp. 27-52. DOI:10.1371/journal. pone.0075227.

Authors
Danilova Irina G.
Institute of medical cell technologies;
Institute of Immunology and Physiology of UB RAS.
Russian Federation, 620149, Yekaterinburg, May Day str., 106
ig-danilova@yandex.ru

Yushkov Boris G.
Institute of medical cell technologies; Institute of Immunology and Physiology of UB RAS
Russian Federation, 620149, Yekaterinburg, May Day str., 106
b.yushkov@iip.uran.ru

Kazakova Irina A.
Institute of medical cell technologies
Russian Federation, 620026, Yekaterinburg, Karl Marx str., 22a
brykina_irina@mail.ru

Brilliant Svetlana A.
Institute of medical cell technologies 
Institute of Immunology and Physiology of UB RAS
Russian Federation, 620026, Yekaterinburg, Karl Marx str., 22a
svetlana.brilliant@bk.ru

Abidov Mussa T.
Institute of immunopathology
Russian Federation, 121351, Moscow, Molodogvardeyskaya str., 57

Received 14.09.2016

For citation:
Danilova I.G., Yushkov B.G., Kazakova I.A., Brilliant S.A., Abidov M.T. Rol' makrofagov v reparativnoj regeneracii pochek [Role of macrophages in the reparativny regeneration kidney] Vestn. Ural. Med. Akad. Nauki. – Journal of Ural Medical Academic Science. 2016, no. 4, pp. 17–22. DOI: 10.22138/2500-0918-2016-14-4-17-22 [In Russ.]

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