The role of Macrophages in the Stimulation of Pancreatic β-Cells Proliferative Activity in Experimental Diabetes Mellitus

Bulavintseva T.S., Danilova I.G.

Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences; Institute of Medical Cellular Technologies, Yekaterinburg, Russian Federation

Abstract.
Our study demonstrated that the modulation of the functional activity of macrophages under decompensated insulin diabetes increases the proliferative activity of β-islet cells.

Keywords:
alloxan diabetes, pancreatic islet, compensation

REFERENCES
1. Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG. Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol, 2008, 155:173–181
2. Singh B, Nikoopour E, Huszarik K, Elliott JF, Jevnikar AM. Immunomodulation and regeneration of islet Beta cells by cytokines in autoimmune type 1 diabetes. J Interferon Cytokine Res, 2011, 31(10):711–719
3. Medvedeva S.Ju., Bulavinceva T.S., Danilova I.G., Gette I.F., Sencov V.G. Toxic effect of alloxan in the dynamics of alloxan diabetes. Vestnik ural'skoj medicinskoj akademicheskoj nauki, 2012, №3, С.30–33
4. Abidov M.T. Immunotropic activity of Tamerit. Bjulleten' jeksperimental'noj biologii, 2000, prel. 3: 11–19.

Authors:
Bulavintseva Tatiana S., 
tbulav@e1.ru
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
Junior Researcher
Russian Federation, 620049, Yekaterinsburg, Pervomajskaja st., 106

Danilova Irina G., 
ig-danilova@yandex.ru
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
Dr. Sci (biology), Head of the Laboratory of Morphology and Physiology
Russian Federation, 620049, Yekaterinsburg, Pervomajskaja st., 106
Institute of Medical Cellular Technologies
Russian Federation, 620036, Yekaterinsburg, Soboleva st., 25