Serotonin and Natural Killer Cells: the Value in Immunoregulation of Infectious Processes

Balmasova I.P., Staurina L.N., Timchenko O.L., Eremina O.F., Gul’tyaev M.M.

Moscow State University of Medicine and Dentistry
named after A.I. Evdokimov, Russian Ministry of Health, Moscow, Russian Federation

Abstract.
In recent years, a significant role of serotonin is defined in the development of immune processes in a wide range of bacterial, protozoal and viral infections. Through the corresponding cell receptors serotonin regulates the immune system cell migration, proliferation, phagocytosis, the generation of superoxide anions, cytokine production, cytotoxic effects, provides associated complications such as chronic fatigue syndrome, irritable bowel syndrome, etc. This study shows the regulatory role of serotonin in the immune system on the example of the formation of liver fibrosis in chronic hepatitis B and C patients. It was found that the primary mechanism for such regulation is not only serum serotonin and serotonin, which is composed of CD16+CD56+ cells (natural killer cells).

Keywords:
serotonin, natural killers, chronic hepatitis B and C, liver fibrosis, immunohistochemistry

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Authors
Balmasova Irina Petrovna,
iri.balm@mail.ru
Moscow State University of Medicine and Dentistry named after A.I.Evdokimov
Doctors of Medicine, Professor, the Head of Laboratory of Pathogenesis and Treatment of Infectious Diseases of Research Institute of Medicine & Dentistry
Delegates' str., 20-1, Moscow, 127473, Russian Federation

Staurina Lidiya Nikolaevna,
kuba_daleko@list.ru
PhD, junior researcher of Laboratory

Timchenko Olga Leonidovna,
otimchenko@mail.ru
MD, Associate Professor of Chair of Infectious Diseases and Epidemiology

Eremina Olga Fedorovna,
immunolab@mail.ru
MD, Leading researcher of Laboratory

Gul’tiaev Maksim Mikhailovich, immunomax@mail.ru
PhD, Senior researcher of Laboratory