CASES OF CEREBRAL CRYPTOCOCCOSIS ON THE BACKGROUND OF COMBINED PATHOLOGY WITHOUT HIV-INFECTION
DOI: 10.22138/2500-0918-2018-15-6-779-784
O.V. Kozlovskaya, G.N. Shestakova, N.N. Kamka, E.N. Efanova
Budget Institution of Hanty-Mansy Autonomous Region Surgut District Clinical Hospital, Surgut, Tyumen Region, Russian Federation;
Budget Institution of Higher Education Surgut State University, Surgut, Tyumen Region, Russian Federation
Abstract. Objective. To study the peculiarities of cerebral cryptococcosis development in patients without HIV infection. Materials and methods. Medical records of hospitalized patients (form 058/y). When examining the patients, HIV infection was excluded using an enzyme-linked immunosorbent assay (ELISA) technique and polymerase chain reaction (PCR). The diagnosis of cryptococcosis was confirmed by the detection of Cryptococcus neoformans antigens in the cerebrospinal fluid using the latex agglutination reaction. Additionally, instrumental studies (echocardiography, computed tomography of the brain) were performed. Results. Patients underwent antimycotic therapy with amphotericin B and fluconazole. Complex antibacterial therapy and immunotherapy were carried out to threat other pathologies. The result was clearance of Cryptococcus from the cerebrospinal fluid and recovery of patients. Conclusion. The peculiarity of these cases was that the paients suffered simultaneously from cryptococcal, tick-borne and staphylococcal infections. The condition for successful treatment of these cases was early bacteriological and immunological diagnostics and timely adequate antimycotic therapy.
Keywords: cerebral cryptococcosis, amphotericin B, fluconazole, meningitis, Cryptococcus neoformans
There is no conflict of interest
Contact details of the corresponding author:
Olga V. Kozlovskaya
kozlovskayaOV@surgutokb.ru
Received 23.04.2018
For citation:
Kozlovskaya O.V., Shestakova G.N., Kamka N.N., Efanova E.N. Cases of cerebral cryptococcosis on the background of combined pathology without HIV-infection. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 6, pp. 779–784. DOI: 10.22138/2500-0918-2018-15-6-779-784 (In Russ)
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Authors:
Olga V. Kozlovskaya,
Cand. Sci. (Med.), Head of the Infectious Disease Department
Hanty-Mansy Autonomous Region Surgut District Clinical Hospital
Energetikov St., 14 Surgut, Tyumen Region, Russian Federation, 628400
kozlovskayaOV@surgutokb.ru
Galina N. Shestakova,
Cand. Sci. (Med.), Excellent Worker of Public Health of the Russian Federation, Head Doctor
Hanty-Mansy Autonomous Region Surgut District Clinical Hospital
Energetikov St., 14 Surgut, Tyumen Region, Russian Federation, 628400
surgutokb@surgutokb.ru
Nadezhda N. Kamka,
Doctorate Student,
Budget Institution of Higher Education Surgut State University, Medical Institute, Department of Infectious, Skin and Venereal Diseases
Lenin Av., 1, Surgut, Tyumen Region, Russian Federation, 628400
kn89@mail.ru
Elena N. Efanova,
Cand. Sci. (Med.), Assistant Professor
Budget Institution of Higher Education Surgut State
University, Medical Institute, Department of Infectious,
Skin and Venereal Diseases
Lenin Av., 1, Surgut, Tyumen Region, Russian Federation, 628400
el.efanova2011@yandex.ru
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)