Content of Autoantibodies and Their Physiological Significance in Regulation of Homeostasis in Inhabitants of Arctic Russia
Ljutfalieva G.T.
Federal State Scientific Institution Institute of Environmental Physiology, Ural Branch Russian Academy of Science, Arkhangelsk, Russian Federation
Abstract. The content of autoantibodies to all tested antigens (oxidized low-density lipoproteins, GAD, insulin, cells of Langerhans islets, annexin-V, phosphatidylserine, single and double helix of DNA, thyroid-stimulating hormone receptor, thyroid peroxidase, IFN-α) in healthy people was studied using enzyme immunodetection. The research revealed a wide range of autoantibodies with various specificity and a high level of autoantibody increased concentrations (from 1% to 38.42% depending on the specificity) in blood of humans, living in arctic regions of Russia. Autoantibody formation was shown to be a physiological process. Within the set limits increasing the autoantibody concentrations seems to be a defense physiological reaction directed at elimination of autoantigenes and maintenance of homeostasis due to age-related, seasonal, hormonal and metabolic changes.
Keywords: autoantibodies, autoantibody formation, regulation of homeostasis
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Authors
Ljutfalieva Gjulnara T.
Federal State Scientific Institution Institute of Environmental Physiology, Ural Branch Russian Academy of Science, Arkhangelsk, Russia
Doctor of Science, M.D.. The Head of The Laboratory of Ecological Immunology
Russian Federation 163000, Arkhangelsk, prospekt Lomonosova, 249
e-mail: gulnara.science@mail.ru