CONTENT OF LYMPHOCYTES WITH MARKERS CD8+ AND CD95+ IN WOMEN 40-60 YEARS OLD IN THE ARCTIC REGION IN NORMAL AND IN PATHOLOGY
DOI: 10.22138/2500-0918-2021-18-3-209-216
T.B. Sergeeva, O.S. Morozova,
E.Yu. Shashkova, O.E. Filippova, L.S. Shchegoleva
N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Arkhangelsk, Russian Federation
Abstract. The natural discomfort of the North is determined by a combination of geographical, climatic, hydrological and other conditions and has an adverse impact on human health. Arterial hypertension (arterial hypertension) in the inhabitants of the North often proceeds malignantly, gives a high frequency of complications in the form of damage to target organs and is one of the most frequent and typical diseases in extreme conditions of nature and work. Early detection of hypertension, timely treatment that improves the quality of life of a person, especially women aged 40-60 years in conditions of increasing the retirement age, is extremely important. To determine the levels of cytotoxic activity and apoptosis in women 40-60 years old with a history of chronic pathology (arterial hypertension) and practically healthy (control). The complex of immunological examination of people included the determination of leukogram, phagocytic activity of neutrophils, phenotyping of lymphocytes: CD8+ (T-suppressor cells), CD95+ (Fas-ligand), using the method of indirect immunoperoxidase reaction using monoclonal antibodies in 116 women 40-60 years old living in the Far North of the Russian Federation (Nadym, Yamal-Nenets Autonomous District and Pinega, Arkhangelsk region). Among them: 46 people — persons with a history of chronic pathology (arterial hypertension) and 70 people — practically healthy persons. Thus, in women 40-60 years old with arterial hypertension, there is an increased content of the total number of lymphocytes, T-suppressors (CD8+), Fas-ligand (CD95+) in 4,30-60,90% of cases, depending on the indicator. Among healthy women aged 40-60 years, an increased content of T-suppressors (CD8+) and Fas-ligand (CD95+) in 47,88 and 21,12% of cases, respectively, indicates that they are at risk of developing hypertension.
Keywords: Far North, arterial hypertension, cytotoxic activity, apoptosis, phagocytosis
There is no conflict of interest.
Contact details of the corresponding author:
Tatyana B. Sergeeva.
tanya — 86@mail.ru
Received 17.06.2021
For citation:
Sergeeva T.B., O.S. Morozova, Shashkova E.Yu., Filippova O.E., Shchegoleva L.S. Content of lymphocytes with markers CD8+ and CD95+ in women 40-60 years old in the arctic region in normal and in pathology. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2021, Vol. 18, no. 3, pp. 209–216. DOI: 10.22138/2500-0918-2021-18-3-209-216 (In Russ)
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Authors
Tatyana B. Sergeeva
Candidate of biological sciences, Researcher of the Laboratory of Physiology of Immunocompetent Cells Physiology
tanya — 86@mail.ru
Olga S. Morozova
Candidate of biological sciences, Researcher at the Laboratory of Immunocompetent Cell Physiology
olia.morozow2011@yandex.ru
Elizaveta Yu. Shashkova
Candidate of biological sciences, Researcher at the Laboratory of Immunocompetent Cell Physiology
eli1255@yandex.ru
Oksana E. Filippova
Candidate of biological sciences, Researcher, Laboratory of Immunocompetent Cell Physiology
oxana_filippova_85@mail.ru
Lyubov S. Shchegoleva
Doctor of Biological Sciences, Professor, Chief Researcher, Head of the Department. laboratory of Physiology of Immunocompetent cells
Shchegoleva60@mail.ru
N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences
249 Lomonosova pr. Arkhangelsk Russian Federation 163000
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)