The Content of Oncofetal Antigens in the Blood of the Inhabitants of the Northern Territories
DOI: 10.22138/2500-0918-2018-15-2-211-217
E.V. Sergeeva
Institute of Environmental Physiology of Federal Center for Integrated Arctic Research Russian Academy of Sciences, Arkhangelsk, Russian Federation
Abstract. Information about the content of reagin in healthy people are rare and contradictory. In the North, the concentration of reagents in blood serum increased, and revealed the relationship of increasing the content of IDE with a reduction in the light period and deterioration of the ion-magnetic situation. Increasing the content of neutral mucopolysaccharides in the epithelium cover increases the resistance of the mucous membrane of the digestive tract and thus is a protective factor. This reaction causes an increase in serum mucopolysaccharide substances known as tumor markers. Thus, both reactions play a protective role, providing protection of mucous membranes and increasing the effectiveness of immune responses.The aim of the study was to establish a causal relationship between the increase in serum IgE and glycoproteins of mucin type, as antigens of the epithelium.Materials and methods of research. A comprehensive examination of 140 people born and living in the Arkhangelsk region was conducted. The contents of cytokines, immunoglobulin, CEA, CA 19-9СА, 72-4 were determined by the method of «competitive» enzyme immunoassay reagents «BIOSOURSE». Phagocytic activity of neutrophils was determined using a test set of chemical company «Realplex» (Chita). The results were processed using the software package»Statistica for Windows version 5.5». The data are presented as mean ± mean error. Correlations between parameters were determined using Spearman's rank correlation and Pearson's linear correlation coefficient, differences were considered significant at a significance level of p<0.05. Results. Coincidence of IgA deficiency and the increase above normal concentration of IgE is virtually absolute, with the only difference being that virtually all individuals with elevated levels of IgE were recorded a deficit of IgA. So of the 140 patients with elevated levels of reagin in 97 cases (to 69.29%) recorded a deficit of IgA. In colon cancer, this pattern is even more pronounced (98.18%), when 54 out of 55 cases of abnormally high IgE concentrations observed deficiency of IDA. In some cases, there was a simultaneous increase in the content of both IgE and IDA. The increase in the content of glycoproteins of mucin type in the blood actually reflects the activation of mucosal mucus production
Keywords: glycoproteins of mucin type, cytokines, immunoglobulins, reagins
Received 09.04.2018
For citation:
Sergeeva E.V. The Content of Oncofetal Antigens in the Blood of The Inhabitants of the Northern Territories. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 2, pp. 211–217. DOI: 10.22138/2500-0918-2018-15-2-211-217 (In Russ)
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Аuthor
Elena V. Sergeeva
Cand. Sci. (Biology), Senior Researcher, Laboratory of Ecological Immunology
Institute of Environmental Physiology of Federal Center for Integrated Arctic Research Russian Academy of Sciences Russian Federation
Russian Federation, 163061, Arkhangelsk, Lomonosov Ave., 249
sergeeva0901@mail.ru
