The Correlation of Dopamine, Sex Hormones, Antisperm Antibodies, Sex Hormone Binding Globuline, cAMP in Aboriginal and Local Male Population of the Arctic Zone of the RF
DOI: 10.22138/2500-0918-2018-15-2-218-228
E.V. Tipisova, I.N. Gorenko, V.A. Popkova, A.I. Popov, S.V. Andronov
Federal Center for Integrated Arctic Research, Russian Academy of Sciences, Arkhangelsk, Russian Federation
Arctic Research Center of the YaNAO — State institution Arctic Research Center of the Yamal-Nenets autonomous district, Salekhard, Russian Federation
Abstract: The aim of the study was to study the modulating effect of dopamine levels in the blood on the hormone content of the pituitary-gonadal system, antisperm antibodies and sex-hormone-binding beta-globulin in various populations of the Arctic. The study involved 122 apparently healthy men aged 22–50 years living on the territories of the Arctic zone of the Russian Federation: the local Caucasoid population permanently residing in the North and the aboriginal population (nomadic and settled). Serum and plasma levels of parameters of the pituitary-gonadal system were determined by methods of enzyme immunoassay and radioisotope analysis. The statistical processing of the data was carried out by nonparametric methods. The maximum content of dopamine (0.626 nmol/L) and the high frequency of detection of its high concentrations (42.8%) in the settled aboriginal population are combined with a decrease in the level of prolactin and the registration of a large percentage of people with low testosterone level (25.8%), more often, an imbalance in the LH content occurs with a decrease in the progenitor hormone progesterone and dehydroepiandrosterone sulfate (11.7%), cAMP (27.3%) and an increase in sex steroid binding globulin (21.7%) and antisperm antibodies compared with the other groups of subjects. The decrease in the level of dopamine (0.472 nmol/L, p=0.03) and the frequency of detection of its high concentrations (25%) in the nomadic population is combined with the registration of high prolactin levels (25%), LH (17.5%), progesterone (28.9%), dehydroepiandrosterone sulfate (10%), testosterone (34.2%). However, high concentrations of dopamine in the nomadic population are also associated with a higher content of sex hormone binding globulin (13.5%) and antisperm antibodies, as well as the registration of low testosterone values in 13.5% of the examined. The median values of dopamine (0.356 nmol / L, p=0.07) and the detection of a minimal percentage of individuals with high its levels (8.3%) in the Caucasoid population were accompanied by persons with high prolactin levels (17.1%), LH (11.1%), progesterone (45.2%) in the absence of a significant imbalance in testosterone, dehydroepiandrosterone sulfate, sex hormone binding globulin levels and a decrease in the level of antisperm antibodies.
Keywords: dopamine, sex hormones, antisperm antibodies, sex hormone binding globuline, cAMP, aborigines, Arctic
Received 09.04.2018
For citation:
Tipisova E.V., Gorenko I.N., Popkova V.A., Popov A.I., Andronov S.V. The correlation of dopamine, sex hormones, antisperm antibodies, sex hormone binding globuline, cAMP in aboriginal and local male population of the Arctic zone of the RF. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 2, pp. 218–228. DOI: 10.22138/2500-0918-2018-15-2-218-228 (In Russ)
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Authors
Elena V. Tipisova
Federal Center for Integrated Arctic Research, Russian Academy of Sciences
Dr. Sci.(Biology), Chief research scientist, Head of Laboratory of Endocrinology named after prof. A.V. Tkachev
Russian Federation, 163000, Arkhangelsk, Lomonosova Ave., 249
tipisova@rambler.ru
Irina N. Gorenko
Federal Center for Integrated Arctic Research, Russian Academy of Sciences
Junior Researcher in lab. of endocrinology named after prof. A.V. Tkachev
Russian Federation, 163000, Arkhangelsk, Lomonosova Ave., 249
pushistiy-86@mail.ru
Viktoriya A. Popkova
Federal Center for Integrated Arctic Research, Russian Academy of Sciences
Cand. Sci. (Biol.), Senior research assistant in lab. of endocrinology named after prof. A.V. Tkachev
Russian Federation, 163000, Arkhangelsk, Lomonosova Ave., 249
victoria-popcova@yandex.ru
Andrey I. Popov
State institution YNAO «Scientific center of Arctic research»
Cand. Sci.(Med.), Head of the medical research sector
Russian Federation, 629008, Salekhard, Respubliki str., 73
Anpopov2007@yandex.ru
Sergey V. Andronov
State institution YNAO «Scientific center of Arctic research»
Cand.Sci.(Med.), Senior research assistant of the medical research sector
Russian Federation, 629008, Salekhard, Respubliki str., 73
sergius198010@mail.ru
