The Ratio of the Content of the Levels of Immunological Parameters and Testosterone Have Men Working Watches in the Northern Seas
DOI: 10.22138/2500-0918-2018-15-2-291-298
M.V. Nekrasova, M.V. Menshikova, O.V. Dolgikh, E.V. Popovskya
Federal Agency for scientific organizations (FANO of Russia) Federal state budget institution of science, Federal research center for integrated study of the Arctic named after academician N. P. Laverov, Russian Academy of Sciences, Arkhangelsk, Russian Federation;
Northern State Medical University, Arkhangelsk, Russian Federation
Abstract. The intensity of changes in the state of immune status and hormonal background depends on the degree of complexity of professional conditions in persons of extreme professions. Purpose of work. To establish the ratio of the content of immunological parameters and testosterone in men in extreme climatic and environmental and professional conditions. Materials and methods of research. Conducted immunological examination 162 people 40–60 years old: employed in hydrographic service of the Arkhangelsk korotkovata method — 42, dlinnovolnovoi — 26; 94 Arkhangelsk not extreme professions. In the peripheral blood was determined by testosterone, leukocytes, lymphocytes CD3+, CD4+, CD5+, CD8+, CD71+, CD95+, CD10+, HLA-DR+. Main results. In male hydrographs of the young age group, the level of total and free testosterone is 18.10±1.14 nmol/l and 12.98±0.73 PG/ml, respectively, compared with persons of Mature age of the same professional group: 14.35±0.93 nmol/l and 7.82±0.92 PG/ml. the Immune status in the examined groups is characterized by elevated concentrations of cytotoxic lymphocytes (CD8+) — in 76,00% of young and in 57,50% of the older age group; natural killers (CD16+) 50,00%; in addition, the content of lymphocytes with receptors to CD3+,CD5+, CD95+ is extremely low, against the background of high lymphoproliferation. The presence of a large number of weak correlation relationships among the studied indicators in both age groups indirectly indicates the independence of hormone concentrations from fluctuations in the content of lymphoid populations except for T-suppressors (CD8). Found that 90,00% of men working in short-shift (16 days), 3 times more common immune imbalances: deficiency of t-cells CD3+, CD5+, CD71+, CD95+, HLA-DR+, CD10+; lower content of total testosterone than men working in long-shift method (265 days). The adaptive decrease of activity and reserve capacity of the immune homeostasis in men of the same age (40.00±5.0 years) in the North is more characteristic of krotkofalowcow and Arkhangelsk not extreme professions.
Keywords: testosterone, immune homeostasis, shift workers, Northern sailors, immunohormonal status
Received 09.04.2018
For citation:
Nekrasova M.V., Menshikova M.V., Dolgikh O.V., Popovskya E.V. The Ratio of the Content of the Levels of Immunological Parameters and Testosterone Have Men Working Watches in the Northern Seas. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 2, pp. 291–298. DOI: 10.22138/2500-0918-2018-15-2-291-298 (In Russ)
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Authors
Maria V. Nekrasova
Federal research center for integrated study of the Arctic named after academician N. P. Laverov, Russian Academy of Sciences, Institute of physiology of natural adaptations
Researcher
Russian Federation, 163000, Arkhangelsk, Lomonosov Ave., 249
nekrasova.ifpa@gmail.com
Marina V. Menshikova
Northern State Medical University
Cand. Sci. ( Biol.), Associate Professor of Histology, Cytology and Embryology
Russian Federation, 163000, Arkhangelsk, Troitsky, 51
menshikovamv1961@yandex.ru
Olga V. Dolgikh
Northern State Medical University
Cand. Sci. ( Biol.), Associate Professor of Histology, Cytology and Embryology
Russian Federation, 163000, Arkhangelsk, Troitsky, 51
menshikovamv1961@yandex.ru
Ekaterina V. Popovskaya
Federal research center for integrated study of the Arctic named after academician N. P. Laverov, Russian Academy of Sciences, Institute of physiology of natural adaptations
Senior researcher
Russian Federation, 163000, Arkhangelsk, Lomonosov Ave., 249
miakati15@gmail.com
