Modern View of the Pathogenesis of Human Papillomavirus Infection (Literary Review)

Bazhukova N. N., Vozovik A. V.

Scientific and Practical Center «Bonum», Yekaterinburg, Russian Federation

Abstract.

Human papillomavirus infection is the most common sexually transmitted infection. Most often the human papilloma virus infects young women of reproductive age. Currently, this infection is considered an etiological factor for cervical cancer, which is the main cause of cancer death among women of reproductive age. This review presents a modern view of the etiology and pathogenesis of human papillomavirus, which will help to understand the mechanisms of malignant transformation of cells when infected with HPV. Just reflects the role of estrogen in the pathogenesis of human papillomavirus.

Keywords:

human papillomavirus, epidemiology, pathogenesis, estrogens

REFERENCES
1. Prilepskaya V.N., Rogovskaya S.I., Kondrikov N.I. Dry GT Human papillomavirus infection: diagnosis, treatment and prevention. M: MEDpress Inform, 2007.
2. Prilepskaya V.N., Bebneva T.N., Shilyaev A.Y. etc. Leukoplakia cervix associated with HPV infection. Ros.vestn.akushera gynecologist. 2012, 12 (4): 108-9.
3. Podistov Y.I. The role of HPV in the development of pre-cancer and cervical cance. Clinical and laboratory diagnosis. 2003, 5: 44-49.
4. Rogovskaya S.I. Human papillomavirus infection and cervical patholog. — 2nd ed. — M.: GEOTAR Media, 2008.
5. Cervix, vagina, vulva. Physiolo, pathology, aesthetic correction: a guide for practitioners. Ed. S.I. Rogowska, E.V. Lime. – M: Publishing magazine Status praesens, 2; s.322 -328 .
6. Kiselev V.I., Ashrafyan L.A., Budarina S.O., Kiselev O.L. Fingers and other etiological role of human papillomavirus in cervical cancer development: genetic and pathogenic mechanisms, treatment options and prevention. Ginekologiya. — 2004. — V.6. — № 4. Cervix. Cytological atlas. E. Titmus, K.Adams; lane. with ang. ed. N.I. Kondrikova. — M.: Practical Medicine, 200; p.106 -112

8. Rogovskaya S.I. HPV infectio. — 3rd editio. Rev. and add. — M.: Geotar Media, 2010. — 240c.
9. Clinical kolposkopiya. The illustrated management. B. S. Apgar, G. L. Botsman, M. Shpitser; the lane with English Under the general editorship of V. N. Prilepskaya. – M.: Applied medicine, 2012; page 144.
10. Burd E.M. Human papillomaviruses and cervical cancer. Clin Mikrobiol Rev 2003; 16:1-17.
11. Krueger H., Gallagher R., Stuart G., Williams D. HPV and other infections agents in cancer. — Oxford Universsity press, 2010. — P. 540.
12. Forman D., Martel C. de, Lacey C.J. et al. Global burden of human papillomavirus and related diseases in ICO. WHO Monograph. HPV and disease prevention. Vaccine .- 2012.-20 Nov. – Vol.30. – Suhhl. 5. – P.F12 – URL: www. sciencedirect.com
13. Forman D., Martel C. de, Lacey C.J. et al. Global burden of human papillomavirus and related diseases in ICO. WHO Monograph. HPV and disease prevention. Vaccine .- 2012.-20 Nov. – Vol.30. – Suhhl. 5. – P.F12 – URL: www. sciencedirect.com
14. Thomas M.C., Chiang C.M. E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradacion. Mol Cell 2005; 17: 251-264.
15. Lee C., Leimins L.A. Role of the PDZ domein-bilding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31. J Virol 2004; 78: 12366-12377.
16. Grm H.S., Banks L. Degradation of hDlg and MAGls by human papillomavirus E6 is E6-AP-independent. J Gen Virol 2004; 85: 2815-2819.
17. Doorbar J., Quint W., Banks L. et al. The Biology and Life-Cycle of Human Papillomaviruses In ICO/WHO Monograph. HPV and disease prevencion. Vaccine. – 2012. – 20 Nov. – Vol. 30. — Suppl. 5. –P. F55. – URL: www.sciencedirect.com.
18. National Cancer Institute. Clinical trials. — URL: htpp: // www.cancer. Gov. clinicatrials/search/ resuits? protocolsearschid=9718014 (last accessed May 2012).
19. Lowy D.R., Schiller J.T. Reducing HPV-associated cancer globally. Cancer prev. Res (Phila). – 2012. – Vol.5 (1). – H.18-23.
20. Pim D., Massimi P., Dilworth S.M., et al. Aktivation of the proteinkinase B pathway by the HPV- 16 E7 oncoprotein occurs through a mechanism involving interaction whit PP2A. Oncogene 2005; 24: 7830-783.
21. Longworth M.S., Laimins L.A. Pathogenesis of human papillomavirus in differendiating epithelia. Microbiol Molecul Biol Rev 2004; 2: 342-350.
22. Bosch F.Х., Tsu V.,Vorsters Van Damme P., Kane M.A. Papillomavirus infections and related diseases in ICO. WHO Monograph. HPV and disease prevencion. Vaccine. – 2012. – 20 Nov. – Vol. 30 – Suppl. 5. –P. F55. – URL: www.sciencedirect.com.

Authors
Bazhukova Natalia N. 
sotnikowa@list.ru
Obstetrician-gynecologist
Vozovik Anastasia V. 
vosovik@bonum.info
MD, Head of the Laboratory of reproductive health
Scientific and Practical Center «Bonum»
Russian Federation, Yekaterinburg, 620000, st. Bardeen 9a