Comparative morphological investigation of osteoinductive characteristics for different diamond-like carbons films for the fixator covering in conditions of osteoporosis (Experimental results)
DOI: 10.22138/2500-0918-2018-15-4-612-618
S.V. Gyulnazarova, A.A. Ganzha, J.P. Kudriavtzeva, A.P. Rubshtein
Ural State Medical University, Yekaterinburg, Russian Federation;
Ural Institute of Traumatology and Orthopaedics n.a. V.D. Chaklin, Yekaterinburg, Russian Federation;
M.N. Micheev Institute of Metall Physics UB RAS, Yekaterinburg, Russian Federation
Abstract. The article presents comparative results of the experimental morphological investigation of the osteoporotical bones reaction to the use of standard steel wires and wires with two types of covering with nanostructuring nonresorptive diamond-like carbons: hard diamond-like carbon and nitrogencontaining carbon. Aim. Comparative morphological investigation of reaction of osteoporotic bone on diamond-like wires covering used at ewxperiments. Materials and methods. Experiments included 104 laboratory Vistar rats with modeled osteoporosis, which was diagnosed after 3-3.5 months. Then wires were led into operated limbs. Results. The use of standard steel wires was accompanied by osteoporosis activity in rats bones, such as increasing of the wire canal diameter and forming in it thick fibrose capsule around the wire. Wires with nitrogen-containing carbon were accompanied by the bone reaction analogous to the reaction of osteoporosis rats on the implantation of standard steel wires. Wires with hard diamond-like carbon stimulated osteogenesis in interface “bone-wire”. This covering provided preservation of wire canal diameter without change and the absence of fibrotic capsula in it at all time of experiment. Conclusion. Significant osteoinductive effect of hard diamond-like carbon in osteoporotic conditions was proved in this investigation.
Keywords: bone, osteoporosis, osteogenesis, wire, nonresorptive diamond-like carbons, experiment
Received 04.07.2018
For citation:
Gyulnazarova S.V., Ganzha A.A., Kudriavtzeva J.P., Rubshtein A.P. Comparative morphological investigation of osteoinductive characteristics for different diamond-like carbons films for the fixator covering in conditions of osteoporosis (Experimental results). Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 4, pp. 612–618. DOI: 10.22138/2500-0918-2018-15-4-612-618 (In Russ)
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Authors:
Stella V. Gyulnazarova
Institute of Traumatology and Orthopaedics n.a. V.D. Chaklin
Ural State Medical University
Dr. Sci. (Med.), Professor, Chif scientific worker
Russian Federation, 620028, Yekaterinburg, Repin str. 3
yand@pm.convex.ru
Alexandr A. Ganzha
Ural Institute of Traumatology and Orthopaedics n.a. V.D. Chaklin
Cand. Sci. (Med.), doctor-ordinator
Russian Federation, Yekaterinburg, Bankovsky 7
gans_aa@mail.ru
Anna P. Rubshtein
M.N. Miheev Institute of Metall Phisics UB RAS
Cand. Sci. (Phisic-Mathem.), Head scientific worker
Russian Federation, 620108, Yekaterinburg, S. Kovalevsky str., 18
rubshtein@imp.uran.ru
