Impact of PPARG (Pro12Ala) Polymorphism on Early Debut of Obesity in Children
DOI: 10.22138/2500-0918-2018-15-1-42-47
O.P. Kovtun, M.A. Ustyuzhanina
Ural State Medical University,Yekaterinburg, Russian Federation
Abstract. The aim of the study was to study the potential relationship between PPARG gene polymorphism (Pro12Ala) and over nutrition in children under 2 years of age, who formed obesity in adolescence. Methods. A retrospective study included 62 obese children (BMI greater than 2.0 SDS) aged 10 to 17 years 5 months. Results. The frequency of polymorphic genotypes of PPARG gene in children with obesity are 66.1% (CC genotype), 30.6% (CG genotype), 3.2% (GG genotype). A reliable association of the polymorphism of PPARG Pro12Ala gene (C> G) with body weight at birth (p = 0.025), at 6 months (p = 0.021) and at 18 months of life (p = 0.025) was revealed. A reliable relationship between PPARG gene polymorphism and body weight gain up to 18 months (p = 0.014) was found. Carriers of the polymorphic allele G (CG / GG genotypes) gained weight an average of 0.99 kg more than patients with the CC genotype of the Pro12Ala polimorphism in the first 18 months of life. The protective effect of breastfeeding on over-nutrition in infants is established. The conclusion. The established regularities are fundamental importance in the understanding of nutritional programming in the early stages of ontogeny and also open new possibilities for correcting overnutrition in early age with the help of nutrigenetics.
Keywords: PPARG gene, children, obesity, nutrition programming, early overnutrition
Received 25.12.2017
For citation:
O.P. Kovtun, M.A. Ustyuzhanina. Impact of PPARG (Pro12Ala) Polymorphism on Early Debut of Obesity in Children. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 1, pp. 42–47. DOI: 10.22138/2500-0918-2018-15-1-42-47 (In Russ)
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Authors
Ol'ga P. Kovtun
Dr. Sci. (Med.), Professor, Corresponding Member, Russian Academy of Sciences
kovtun@usma.ru
Margarita A. Ustyuzhanina
Assistant of the Department of Pediatrics
ustmargarita@mail.ru
Ural State Medical University
str. Repin 3, Yekaterinburg, 620028, Russian Federation