Resistance to nitrosoguanidine and 5-bromouracil of tumor cells with mutator phenotype

Chereshnev V.A., Golyasnaya N.V., Chereshneva M.A., Zhizgin N.K.

Abstract.

Resistance to N-methyl-N’-nitro-N-nitrosoguanidin and 5-bromouracil, imbalance of mismatch repair genes expression confirmed the mutator phenotype of tumor cells from patients with colorectal cancer. Disturbance of repair gene expression in the cells, which are resistant to 5-fluorouracil, tomudex, cisplatin and their combination with leucovorin was determined by us previously.

Keywords:

colorectal cancer, primary cell lines, MSH2, MSH3, MSH6 genes

Authors
Chereshnev Valery A.
Institute of an immunology and physiology of URO Russian Academy of Sciences, Yekaterinburg;
Golyasny Nadejda V. 
Institute of a bionomics and genetics of microorganisms of URO Russian Academy of Sciences, Perm, Russia
Chereshneva Margarita V
Institute of an immunology and physiology of URO Russian Academy of Sciences, Yekaterinburg;
Zhizhin Nikita K. 
Institute of an immunology and physiology of URO Russian Academy of Sciences, Yekaterinburg;
Russia, 620000, Yekaterinburg, Pervomayskaya St., 106