Betamid Influence on Remyelination in Cuprizone-Induced Demyelination in Mice

Korablev A.N., Popova N.A., Tolstikova T.G., Khodakov A.A., Predtechenskaya E.V.

Novosibirsk State University; The Institute of Cytology and Genetics of The Siberian Branch of the Russian Academy of Sciences; N.N. Vorozhtsov Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Science, Novosibirsk, Russian Federation

Abstract.

Our study shows that amid betulonic acid (ABA) exhibits moderate protective on myelin in cuprizone-induced demyelination in mice. Average corpus callosum area is increased by 16 % according to MRI-studies and histological examinations show that brain tissues remain more intact in mice receiving ABA in comparison with control animals with demyelination.

Keywords:

amid betulonic acid, cuprizone-induced demyelination, multiple sclerosis

REFERENCES
1. Jana Blazevski, Filip Petkovic, Miljana Momcilovic, Reinhard Paschke, Goran N Kaluderovic, Marija Mostarica Stojkovic, Djordje Miljkovic. Betulinic acid regulates generation of neuroinflammatory mediators responsible for tissue destruction in multiple sclerosis in vitro. Acta Pharmacologica Sinica, 2013, 34: pp. 424–431.
2. Lu, J., Zheng., Y. L., Wu, D. M., Luo, L. “Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by d-galactose” Biochem. Pharmacol. 2007, 74, pp. 1078-1090
3. Shih Y., Chein C., Wang Y., Fu Y. “Ursolic acid protects hippocampal neurons against kainite-induced excitotoxicity in rats” Neurosci. Lett.2004, 362, pp. 136-140
4. Sergey F. Vasilevsky, Anastasiya I. Govdi, El’vira E. Shults, Makhmut M. Shakirov, Irina V. Sorokina, Tatyana G. Tolstikova, Dmitry S. Baev, Genrikh A. Tolstikova, Igor V. Alabugin. Efficient Synthesis of the First Betulonic Acid -Acetylene Hybrids and their Hepatoprotective and Anti-Inflammatory Activity. Bioorg Med Chem. 2009 Jul 15; 17(14): p. 5164-9.
5. Andrew J. Steelman, Jeffrey P. Thompson, Jianrong Li. Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication. Neurosci Res. 2012 January; 72(1): pp. 32–42.

Authors
Korablev Alexey N., korablevalexeyn@gmail.com
Novosibirsk State University
student of Medicine
Russian Federation, 630090, Novosibirsk, Pirogova prospekt, 2

Popova Nelly A., nelly@bionet.nsc.ru
Novosibirsk State University
professor

Tolstikova T.G., nelly@bionet.nsc.ru
Novosibirsk State University
professor
N.N. Vorozhtsov Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Science
Head of laboratory

Khodakov Anton A., student_med@mail.ru
Novosibirsk State University
intern

Predtechenskaya Elena V., nelly@bionet.nsc.ru
Novosibirsk State University
professor