Influence of neutropenia on the state of the immune status in persons working on the Svalbard archipelago

DOI: 10.22138/2500-0918-2019-16-2-71-77

S.N. Balashovа, L.K. Dobrodeeva

N. Laverov Federal Center for Integrated Arctic Research, Arkhangelsk, Russian Federation

Abstract. Aim. To determine the etiological factors of neutropenia and its effect on the immune responses of people living in the Arctic territories. Materials and methods. The study of peripheral venous blood parameters in 75 residents of the Barentsburg of the Svalbard archipelago. The concentrations of IL-1β, TNF-α, IL-6 (Bender Medsystems, Austria) were determined by enzyme immunoassay on an automated analyzer “Evolis” (Bio-RAD, France). Results. Adaptation of a person in adverse climatic conditions in the Svalbard archipelago is associated with an increase in the migration of blood cells into the tissue, which can manifest itself as transient neutropenia, monocytopenia, lymphopenia and the risk of environmentally dependent immunodeficiency. On the background of neutropenia, the content of monocytes activated by T-cells with transferrin receptor (CD71+) and cells capable of proliferating CD10+ decreases; lower concentration of pro-inflammatory cytokine IL-1β. Conclusion. Northern neutropenias are likely to be formed as a result of the influence of several reactions, among which may be autoimmune and redistributive. The relationship of neutropenia with monocytopenia and lymphopenia is possible under the influence of a complex of biologically active components secreted by phylogenetic early neutrophils on blood cells of later origin.

Keywords: neutropenia, immune status, cytokines, Svalbard archipelago

Received 15.04.2019.

For citation:
Balashovа S.N., Dobrodeeva L.K. Influence of neutropenia on the state of the immune status in persons working on the Svalbard Archipelago. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 2, pp. 71–77. DOI: 10.22138/2500-0918-2019-16-2-71-77 (In Russ)

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Authors
Svetlana N. Balashova
Cand. Sci. (Biolog), Senior Researcher of the Laboratory of regulatory mechanisms of immunity of the Institute of Environmental Physiology
ifpa-svetlana@mail.ru

Liliya K. Dobrodeeva
Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation, Director of the Institute of Environmental Physiology
dobrodeevalk@mail.ru

N. Laverov Federal Center for Integrated Arctic Research
Russian Federation, 163000, Arkhangelsk, nab. Northern Dvina, 23

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