Effect of peptide hormone from the stomac and digestive enzymes on the activity of immune reactions of residents of the northern territories of the Russian Federation
DOI: 10.22138/2500-0918-2019-16-2-153-158
E. A. Menshikova
Institute of Physiology of Natural Adaptations of the Federal State Budgetary Institution of Science of the Federal Research Center for the Integrated Study of the Arctic named after Academician N. P. Laverov of the Russian Academy of Sciences, Arkhangelsk, Russian Federation
Abstract. In this paper, we surveyed adult residents of the North with diseases of the gastrointestinal tract and without signs of damage to the organs of the gastrointestinal tract. It is known that diseases of the digestive system are related to the indicator pathology of the inhabitants of the northern territories [1]. The data obtained suggest that the level of content of mediators of digestion (gastrin-17, neuropeptide SP) in the blood have a significant impact on the immune status of the body and on tolerance to food antigens. It is known that the functioning of the immune system is closely related to the activity of the gastrointestinal tract, including its hormonal functions. The purpose of the study is to identify the relationship of the influence of mediators of digestion on the activity of immune reactions and the state of the gastrointestinal tract of residents of the northern territories of the Russian Federation. Materials and methods. A survey of adults of the North. The examination included the study of lymphocyte phenotypes — an indirect immunoperoxidase reaction using monoclonal antibodies and flow cytometry. The number and ratio of hemogram cells were counted in blood smears stained according to the Romanovsky-Giems method. The levels of gastrin-17, enzymes, neuropeptide SP, as well as immunoglobulins and cytokines were determined by ELISA. Results. Low levels of gastrin-17 form a risk for the development of the reagin defense mechanism against the deficiency of the neurotransmitter SP and class A. immunoglobulin. It has been revealed that the level of digestive enzymes in peripheral blood increases in diseases of the gastrointestinal tract. The increased content of enzymes (α-amylase, AST and ALT) stimulate the secretion of TNF-α, reagins against the background of increasing levels of killer and cytotoxic lymphocytes. Conclusion. The lack of vasomotor function of the gastrointestinal tract as a result of a deficiency in the content of gastrin-17 and the neurotransmitter SP in patients is associated with a lack of IgA and the risk of the development of antibody production by a reagin-mediated defense mechanism. Elevated levels of digestive enzymes initiate TNF-α secretion with an increase in the activity of cell-mediated cytotoxicity and the development of an antibody-dependent response involving reagins.
Keywords: immune reactions, hormones, enzymes, diseases of the gastrointestinal tract, residents of the northern territories of the Russian Federation
Received 15.04.2019.
For citation:
Menshikova E.A. Effect of peptide hormone from the stomac and digestive enzymes on the activity of immune reactions of residents of the northern territories of the Russian Federation. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 2, pp. 153–158. DOI: 10.22138/2500-0918-2019-16-2-153-158 (In Russ)
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Аuthor
Elena A. Menshikova
Federal State Budgetary Institution of Science, Federal Research Center for Integrated Study of the Arctic, Academician NP Laverov, Russian Academy of Sciences, Arkhangelsk.
Cand. Sci. (Biology), Senior Researcher
Northern Dvina str. 23 Arkhangelsk Russian Federation 163000
vecaup24@yandex.ru
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