POSSIBLE MECHANISMS OF THE PYRUVATE SHIFT FORMATION IN THE BLOOD OF PEOPLE LIVING IN THE NORTH
DOI: 10.22138/2500-0918-2018-15-2-176-183
O.V. Zubatkina, M.Ja. Malahova, A.A. Popov
Northern State Medical University, Arkhangelsk, Russian Federation;
Mechnikov North-Western State Medical University, St.Petersburg, Russian Federation
Abstract. Successful adaptation of the human body to the conditions of the north is based on the invariant, specific direction of the metabolic processes, providing a transition to a different, «polar» (Panin L.E., 1978) type of metabolism. Materials and methods. The parameters of carbohydrate and lipid metabolism of blood plasma were determined in 106 healthy volunteers living in Arkhangelsk for at least 20 years. All volunteers (41 men and 65 women) were engaged in intellectual labor, their average age was 32 (8,7) years and body mass index was 23,4 (2,1). Results and discussion. It was found that 78% of the examined people have specific blood metabolite profile with the level of pyruvate exceeding the upper limit of the reference interval. Also, possible mechanisms of the formation of this over-referenced pyruvate level in the blood of the Northern people are observed. The estimation was made of the involvement of AMPK, JAK/STAT, PI-3K signaling in metabolic intracellular rearrangements aimed at covering the increasing energy demands for adaptation to northern conditions. In our opinion, the maintenance of the dynamic equilibrium at a new level of energy supply becomes possible due to a change in the functional role of pyruvate in both catabolic and anabolic processes. As a result, the course of both processes is accompanied by an increase in cytosolic pool of pyruvate and by its increased release from the cells into the bloodstream.
Keywords: north, adaptation, polar metabolism, pyruvate
Received 09.04.2018
For citation:
Zubatkina O.V., Malahova M.Ja., Popov A.A. Possible Mechanisms of the Pyruvate Shift Formation in the Blood of People Living in the North. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 2, pp. 176–183. DOI: 10.22138/2500-0918-2018-15-2-176-183 (In Russ)
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Authors
Ol'ga V. Zubatkina
Northern State Medical University
Doc. Sci. (Biol.), Professor
Russian Federation,163000, Arhangel'sk, prospekt Troickij, 51
ozbiochem@gmail.com
Margarita J. Malahova
Mechnikov North-Western State Medical University
Doc. Sci. (Med.), Professor, Professor of Department of Clinical Biochemistry
Russian Federation, 191015, Sankt-Peterburg, Kirochnaja str., 41
prof-malachova@mail.ru
Andrej A. Popov
Northern State Medical University
Cand. Sci (Biol.), Docent, Assoc.Prof. Department of Clinical Biochemistry, Microbiology and Laboratory Diagnostics
Russian Federation, 163000, Arhangel'sk, prospekt Troickij, 51
biochem66@gmail.com
