The interaction between cytokine-neurotrophic profile and cognitive and functional status in acute ischemic stroke
Kulesh A.A., Kuklina E.M., Shestakov V.V.
Abstract. The role of inflammation in the development and course of stroke and cognitive impairment is important problem. The significance of insulin-like growth factor 1 (IGF-1) in the development of cardiovascular disease and cognitive deficits associated with aging have been studied extensively in recent years. Studies of cumulative effect of these factors on cognitive and functional status of patients with acute ischemic stroke has not been carried out.
Aims: to evaluate the relationship of cytokine-neurotrophic profile with cognitive and functional status in acute ischemic stroke.
70 acute stroke patients were studied with assessment of neuropsychological and functional status. The serum and liquor IL-1β, IL-6, TNFα, IL-10 and IGF-1levels were analyzed. Control group consists of 20 persons without cerebrovascular disease.
The dominance of IL-1β on IGF-1was associated with stroke severity, low executive functions, worse attention and functional outcome. The same results were revealed for dominance of IL-1β on IL-1β-TNFα and IL-6 on IGF-1. Low global cognitive status, processing speed and executive functions were interacted with dominance of IL-1β-IL-10 on IL-1β.Vascular type of cognitive impairment was associated with IL-1β, IL-6 and TNFα dominancy. On the other hand TNFα dominancy was linked with better memory and visual-spatial results.
Thereby the balance between pro- and anti-inflammatory directions of immune response in association with IGF-1-related neuroprotective and neurotrophic activity seems to be the important determinant of cognitive and functional status in acute ischemic stroke.
Keywords: Stroke, neuroinflammation, cytokines, IGF-1, cognitive impairment
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Autors
Kulesh Aleksej A.
Perm State Medical University named after academician EA Wagner, Perm, Russia. M.D., PhD, Associate Professor.
Russian Federation, 614990, Perm', str. Petropavlovskaja, 26
aleksey.kulesh@gmail.com
Kuklina Elena M.
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russia.Doctor of Science, Biology. Principal research fellow
Russian Federati, 614081, Perm', str. Goleva 13
ibis_07@mail.ru.
Shestakov Vladimir V.
Perm State Medical University named after academician EA Wagner, Perm, Russia. M.D., Doctor of Science, Professor, Head of the Department of Neurology
Russian Federation, 614990, Perm', str. Petropavlovskaja, 26
v1amad@mail.ru
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