The Relationship of the Functional Activity of Neutrophilic Granulocytes and Lymphocytes in Peripheral Blood of Arctic Residents

Balashovа S.N., Patrakeeva V.Р.

The Institute of Environmental Physiology, Ural Branch, Russian Academy of Sciences, Archangelsk, Russian Federation

Abstract. Studied the phagocytic activity of peripheral blood neutrophils, depending on the state of the immune system among residents Arctic Nenets autonomous area and the city of Arkhangelsk. Found that the inhabitants of the Arctic lower content of neutrophils in the peripheral blood and their phagocytic activity of protection, due to the periphery of the output of young immature neutrophils. Functional failure of neutrophil granulocytes is compensated an increased intensity of phagocytosis, activity of monocytes and is associated with a low level of apoptosis of granulocytes. Neutropenia is not offset by a shift to the left, increasing the intensity of phagocytosis, amid further reduce the level of apoptosis of granulocytes. Decreased activity of programmed death of neutrophils is associated with low levels of concentration of proinflammatory cytokines, the activity of proliferation, differentiation and apoptosis of lymphocytes.

Keywords: neutrophil, lymphocyte, monocyte, functional activity, proliferation, apoptosis, cytokines, Arctic

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Authors
Balashova Svetlana Nikolaevna ifpa-svetlana@mail.ru
PhD (Biology), senior researcher, laboratory of regulatory mechanisms of immunity
Patrakeeva Veronika Pavlovna repina-veronika@yandex.ru
PhD (Biology), senior researcher, laboratory of regulatory mechanisms of immunity
The Institute of Environmental Physiology, Ural Branch, Russian Academy of Sciences
Russian Federation 163000, Arhangel'sk, pr. Lomonosova, d. 249