THE SIGNIFICANCE OF PERITONIAL FLUID IN THE GENESIS OF INFERTILITY IN WOMEN WITH OVARIAN ENDOMETRIOSIS

Ja. A. Mangileva¹, A.V. Chizhova¹, E.V. Kudrjavceva²,³, D.K. Islamidi²,⁴, A.V. Geet²

DOI: 10.22138/2500-0918-2022-19-2-82-94

¹ State Clinical Hospital No. 14, Yekaterinburg, Russian Federation;
² Ural State Medical university, Yekaterinburg, Russian Federation;
³ Center for Specialized Types of Medical Care “Institute of Cellular Technologies”, Yekaterinburg, Russian Federation;
⁴ Medical center «Garmonyia”, Yekaterinburg, Russian Federation

Abstract. Endometriosis is a common disease, reaching 10-20% among women of reproductive age. Early diagnosis of this disease (at the stage of formation of endometriotic heterotopias) is difficult due to the absence of typical changes in such non-invasive examination methods: MRI scan, ultrasound, CT scan. At the same time, the gold standard for diagnosis is an aggressive surgical approach — laparoscopy, which allows you to see the exact localization and extent of the lesion with endometriosis. Thereby, this requires the search for new methods of timely diagnosis, which would allow diagnosing genital endometriosis at an early stage. This article presents an overview of scientific articles that examine the role of biochemical parameters (various interleukins, tumor necrosis factor alpha, iron, chemokine) in peritoneal fluid. An increase or decrease in these markers makes it possible to reveal if a patient has external genital endometriosis and can be a factor in non-invasive confirmation of the disease.

Keywords: Infertility, external genital endometriosis, peritoneal fluid, diagnosis of endometriosis, peritoneal fluid markers, pregnancy planning

There is no conflict of interest.
Contact details of the corresponding author:
Kudryavtseva Elena Vladimirovna
elenavladpopova@yandex.ru
Received 19.05.2022
For citation:
Mangileva Ja.A., Chizhova A,V,, Kudrjavceva E.V., Islamidi D.K., Geets A.V. The significance of peritonial fluid in the genesis of infertility in women with ovarian endometriosis. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2022, Vol. 19, no. 2, pp. 82–94. DOI: 10.22138/2500-0918-2022-19-2-82-94 (In Russ)

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Authors
Yana A. Mangileva
Ural State Medical University, State Autonomous Healthcare Institution of the Sverdlovsk Region «State Clinical Hospital No. 14».
MD, Obstetrician-gynecologist, Aspirant Resident of the Department of Obstetrics and Gynecology
3 Repin st. Yekaterinburg Russian Federation, 620028
yanaamangileva@mail.ru

Anna V. Chizhova
Ural State Medical University, State Autonomous Healthcare Institution of the Sverdlovsk Region «State Clinical Hospital No. 14»
MD, Obstetrician-gynecologist, Заочный Aspirant Resident of the Department of Obstetrics and Gynecology
3 Repin st. Yekaterinburg Russian Federation, 620028
annabobina17@mail.ru

Elena V. Kudryavtseva
Ural State Medical University. Center for Specialized Types of Medical Care “Institute of Cellular Technologies”.
PhD, MD, assistant professor
3 Repin st. Yekaterinburg Russian Federation, 620028
elenavladpopova@yandex.ru.

Diana K. Islamidi
Ural State Medical University, medical center «Garmonyia”, Yekaterinburg, Russia
PhD, MD, assistant professor
3 Repin st. Yekaterinburg Russian Federation, 620028
dishader@yandex.ru

Andrey V. Geets
Ural State Medical University
Resident of the Department of Obstetrics and Gynecology
3 Repin st. Yekaterinburg Russian Federation, 620028
an_geets@mail.ru